Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2241–2248 | Cite as

Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus

  • Kalina Venkova
  • Graeme Fraser
  • Hamid R. Hoveyda
  • Beverley Greenwood-Van Meerveld
Original Paper

Abstract

Postoperative ileus (POI) is a major cause of postoperative complications and prolonged hospitalization. Ghrelin, which is the endogenous ligand for the growth hormone secretagogue receptor, has been found to stimulate gastric motility and accelerate gastric emptying. The present study investigates whether TZP-101 (0.03–1 mg/kg i.v.), a synthetic ghrelin-receptor agonist, could improve gastrointestinal transit in rats with POI. Since the main factors for the development of POI are the surgical manipulation and the gastrointestinal effects of opioid-receptor agonists used for pain management, the effect of TZP-101 was investigated in rats subjected to surgery, to morphine treatment (3 mg/kg s.c.), or to a combination of both. The results showed that TZP-101 is equally effective against the delayed gastrointestinal transit induced by surgery, by morphine, or by the combination of both interventions. The prokinetic action of TZP-101 was more pronounced in the stomach compared to the small intestine.

Keywords

Ghrelin-receptor agonist Postoperative ileus Gastrointestinal transit 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Kalina Venkova
    • 1
  • Graeme Fraser
    • 2
  • Hamid R. Hoveyda
    • 2
  • Beverley Greenwood-Van Meerveld
    • 1
    • 3
  1. 1.VA Medical Center, Oklahoma Center for NeuroscienceUniversity of Oklahoma Health Science CenterOklahoma CityUSA
  2. 2.Tranzyme PharmaSherbrookeCanada
  3. 3.VA Medical CenterOklahoma CityUSA

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