Digestive Diseases and Sciences

, Volume 53, Issue 10, pp 2714–2718 | Cite as

Therapeutic Effect of Lactobacillus acidophilus-SDC 2012, 2013 in Patients with Irritable Bowel Syndrome

  • Dong Hyun Sinn
  • Ji Hyun Song
  • Hoi Jin Kim
  • Jun Haeng Lee
  • Hee Jung Son
  • Dong Kyung Chang
  • Young-Ho Kim
  • Jae J. Kim
  • Jong Chul Rhee
  • Poong-Lyul RheeEmail author
Original Paper


Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. Lactobacillus acidophilus-SDC 2012, 2013 are new strains isolated from Korean infants’ feces. The potential utility of Lactobacillus acidophilus-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients were randomized into a placebo (n = 20) and probiotics group (n = 20). Four weeks of treatment with L. acidophilus-SDC 2012, 2013 was associated with a reduced score for abdominal pain or discomfort compared to the baseline (P = 0.011). The percent reduction in abdominal pain or discomfort exceeded the placebo scores by more than 20% (23.8 and 0.2% for probiotics and placebo, respectively, P = 0.003). There was a significant difference in the proportion of responders between the probiotics and placebo groups (P = 0.011). There was no drop out or adverse events for either group during the study period. Lactobacillus acidophilus-SDC 2012, 2013 appeared to have a beneficial effect in patients with IBS. Further studies are warranted.


Probiotics Irritable bowel syndrome Lactobacillus acidophilus 



Financial support: The authors were supported, in part, by grants from the Seoul Research and Business Development Program (No. 10582).


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Dong Hyun Sinn
    • 1
  • Ji Hyun Song
    • 2
  • Hoi Jin Kim
    • 1
  • Jun Haeng Lee
    • 1
  • Hee Jung Son
    • 1
  • Dong Kyung Chang
    • 1
  • Young-Ho Kim
    • 1
  • Jae J. Kim
    • 1
  • Jong Chul Rhee
    • 1
  • Poong-Lyul Rhee
    • 1
    • 3
    Email author
  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea
  2. 2.Healthcare System, Gangnam CenterSeoul National University HospitalSeoulKorea
  3. 3.Division of Gastroenterology, Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea

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