Digestive Diseases and Sciences

, Volume 53, Issue 8, pp 2233–2237 | Cite as

Cytokine Levels of TGF-β, IL-10, and sTNFαRII in Type C Chronic Liver Disease

Original Paper

Abstract

Cytokines play a key role in regulation of immunity and inflammation. The aim of the study was to detect serum levels of TGF-β, IL-10, and sTNFαRII in patients with type C chronic liver disease (CLD) and to correlate these with biochemical and histopathological parameters used to assess the severity of the disease. Blood samples were aseptically collected from 90 CLD patients. Cytokine levels were also followed up in 39 chronic hepatitis cases. Levels of the cytokines in 90 CLD patients were significantly higher than in controls. In the follow up patients, 12 were non-responders and the serum levels of cytokines were still elevated after therapy whereas in 27 responders cytokine levels were significantly reduced after therapy and correlated well with biochemical and histopathological parameters. It is inferred that cytokine levels reflect the level of inflammation in chronic hepatitis C virus (HCV) infection and can be used as indirect markers to assess the severity of liver disease.

Keywords

Hepatitis C virus Cytokine levels of TGF-β, IL-10, sTNFαRII 

Notes

Acknowledgment

Authors thankfully acknowledge the financial support of Indian Council of Medical Research, New Delhi, India to carry out this work and providing Senior Research Fellowship to Mr Vikas Verma.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Vikas Verma
    • 1
  • Anita Chakravarti
    • 1
    • 2
  • Premashis Kar
    • 3
  1. 1.Department of MicrobiologyMaulana Azad Medical College & Associated Lok Nayak HospitalsNew DelhiIndia
  2. 2.New DelhiIndia
  3. 3.Department of MedicineMaulana Azad Medical College & Associated Lok Nayak HospitalsNew DelhiIndia

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