Response to Hepatitis B Vaccination in Patients with Celiac Disease
- 186 Downloads
Abnormal immune response to gliadin, genetic, and environmental factors play a role in the pathogenesis of celiac disease (CD). Non-responsiveness to hepatitis B virus (HBV) vaccination is related to genetic features. Certain human leukocyte antigen (HLA) genotypes are more prevalent among non-responders to HBV vaccination. There is also a strong relationship between CD and these HLA genotypes. This study investigates the relationship between CD and non-responsiveness to HBV vaccination, with an emphasis on genotypic co-incidence. No statistically significant difference was noted between the ages and gender of CD patients and control subjects. Baseline serum IgA, IgM, and IgG levels of all CD patients were normal. Responsiveness to HBV vaccination was observed in 17 (68%) CD patients and all (100%) control subjects (P = 0.006). In conclusion, CD should also be sought in unresponders to HBV vaccine who are not immunosuppressed.
KeywordsCeliac disease Hepatitis B Vaccination
- 2.Bai J, Zeballos E, Fried M, Corazza GR, Schuppan D, Farthing MJG, Catassi C, Greco L, Cohen H, Krabshuis JH (2005) WGO-OMGE practice guideline. Celiac disease. World Gastroenterol News 10:6–12Google Scholar
- 10.Farrell RJ, Kelly CP (2002) Celiac sprue and refractory sprue. In: Feldman M, Friedman LS, Sleisenger MH (eds) Sleisenger & Fordtran’s gastrointestinal and liver disease, 7th edn. WB Saunders, Philadelphia, Pennsylvania, pp 1817–1837Google Scholar
- 17.Höhler T, Meyer CU, Notghi A, Stradmann-Bellinghausen B, Schneider PM, Starke R, Zepp F, Sänger R, Clemens R, Meyer zum Büschenfelde KH, Rittner C (1998) The influence of major histocompatibility complex class II genes and T-cell Vbeta repertoire on response to immunization with HBsAg. Hum Immunol 59:212–218PubMedCrossRefGoogle Scholar