Digestive Diseases and Sciences

, Volume 53, Issue 8, pp 2215–2221 | Cite as

Serum Ghrelin Levels in Inflammatory Bowel Disease with Relation to Disease Activity and Nutritional Status

  • Yuksel Ates
  • Bulent Degertekin
  • Ahmet Erdil
  • Halil Yaman
  • Kemal Dagalp
Original Paper


Ghrelin possesses various biological activities—it stimulates growth hormone (GH) release, plays a major role in energy metabolism, and is one of the hormones that affects body composition. It also plays a role in modulating immune response and inflammatory processes. In this study we aimed to determine whether serum ghrelin levels had correlation with markers associated with disease activation. We also investigated any probable relationship between serum ghrelin level and nutritional status. Serum levels of ghrelin and its relationship with disease activity and nutritional status were evaluated in 34 patients with ulcerative colitis (UC), 25 patients with Crohn’s disease (CD), and 30 healthy controls. Serum ghrelin levels, serum IGF-1 and GH levels, and markers of disease activity (sedimentation, C-reactive protein, and fibrinogen) were measured in all subjects. Body composition and nutritional status was assessed by both direct (by anthropometry) and indirect (by bioimpedance) methods. Serum ghrelin levels were significantly higher in patients with active UC and CD than in those in remission (108 ± 11 pg/ml vs. 71 ± 13 pg/ml for UC patients, P < 0.001; 110 ± 10 pg/ml vs. 75 ± 15 pg/ml for CD patients, P < 0.001). Circulating ghrelin levels in UC and CD patients were positively correlated with sedimentation fibrinogen and CRP and was negatively correlated with IGF-1, BMI, TSFT, MAC, fat mass (%), and fat free mass (%). This study demonstrates that patients with active IBD have higher serum ghrelin levels than patients in remission and high levels of circulating ghrelin correlate with the severity of disease and the activity markers. Ghrelin levels in inflammatory bowel disease (IBD) patients show an appositive correlation with IGF-1 and bioelectrical impedance analysis, body composition, and anthropometric assessments. Finally, we arrived at the conclusion that ghrelin level may be important in determination of the activity in IBD patients and evaluation of nutritional status.


Ghrelin Inflammatory bowel disease Ulcerative colitis Crohn’s disease IGF-1 Nutritional status 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Yuksel Ates
    • 1
  • Bulent Degertekin
    • 2
  • Ahmet Erdil
    • 1
  • Halil Yaman
    • 3
  • Kemal Dagalp
    • 1
  1. 1.Department of GastroenterologyGulhane Military Medical AcademyAnkaraTurkey
  2. 2.Faculty of Medicine, Department of GastroenterologyUfuk UniversityAnkaraTurkey
  3. 3.Department of BiochemistryGulhane Military Medical AcademyAnkaraTurkey

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