Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis
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The endoscopic finding of nodular gastritis (NG) is highly associated with presence of Helicobacter pylori infection. How the endoscopic patterns and histopathology of NG change after eradication of H. pylori is unclear. Twenty-one adults (3 men and 18 women) with H. pylori-associated NG found on endoscopy were enrolled for this study. The histological findings included gastritis activity, bacterial colonization, and lymphoid follicles. Repeat endoscopy for the endoscopic as well as histopathological features of gastric biopsy specimens was performed 2 months later after eradication treatment. H. pylori was successfully eradicated in 19 patients. Endoscopic NG disappeared in 12, improved in 5, and was unchanged in 4. After treatment, there was significant improvement in scores for gastritis activity [P < 0.001, 95% confidence interval (CI) 1.31–1.91], bacterial colonization (P < 0.001, 95% CI 0.71–1.14) and follicular gastritis (P = 0.047, 95% CI 0.04–0.52), primarily among patients whose endoscopic pattern resolved completely. The disappearance of nodularity on endoscopy was accompanied by a decrease in follicular gastritis score.
KeywordsNodular gastritis Helicobacter pylori Eradication therapy Lymphoid follicles
The authors would like to thank Dr. Mary Jeanne Buttrey for critical reading and correction of the manuscript.
- 3.Luzza F, Pensabene L, Imeneo M, Mancuso M, Contaldo A, Giancotti L, La Vecchia AM, Costa MC, Strisciuglio P, Docimo C, Pallone F, Guandalini S (2001) Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation. Gastrointest Endosc 53:60–64PubMedCrossRefGoogle Scholar
- 9.Ohara H, Isomoto H, Wen CY, Ejima C, Murata M, Miyazaki M, Takeshima F, Mizuta Y, Murata I, Koji T, Nagura H, Kohno S (2003) Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis. World J Gastroenterol 9:2701–2705PubMedGoogle Scholar
- 10.Luzza F, Pensabene L, Imeneo M, Mancuso M, Giancotti L, La Vecchia AM, Costa MC, Strisciuglio P, Pallone F (2002) Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection. Helicobacter 7:46–52PubMedCrossRefGoogle Scholar