Digestive Diseases and Sciences

, Volume 53, Issue 7, pp 1893–1897 | Cite as

Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis

  • Ming-Jen ChenEmail author
  • Shou-Chuan Shih
  • Tsang-En Wang
  • Yu-Jan Chan
  • Chih-Jen Chen
  • Wen-Hsiung Chang
Original Paper


The endoscopic finding of nodular gastritis (NG) is highly associated with presence of Helicobacter pylori infection. How the endoscopic patterns and histopathology of NG change after eradication of H. pylori is unclear. Twenty-one adults (3 men and 18 women) with H. pylori-associated NG found on endoscopy were enrolled for this study. The histological findings included gastritis activity, bacterial colonization, and lymphoid follicles. Repeat endoscopy for the endoscopic as well as histopathological features of gastric biopsy specimens was performed 2 months later after eradication treatment. H. pylori was successfully eradicated in 19 patients. Endoscopic NG disappeared in 12, improved in 5, and was unchanged in 4. After treatment, there was significant improvement in scores for gastritis activity [P < 0.001, 95% confidence interval (CI) 1.31–1.91], bacterial colonization (P < 0.001, 95% CI 0.71–1.14) and follicular gastritis (P = 0.047, 95% CI 0.04–0.52), primarily among patients whose endoscopic pattern resolved completely. The disappearance of nodularity on endoscopy was accompanied by a decrease in follicular gastritis score.


Nodular gastritis Helicobacter pylori Eradication therapy Lymphoid follicles 



The authors would like to thank Dr. Mary Jeanne Buttrey for critical reading and correction of the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Ming-Jen Chen
    • 1
    Email author
  • Shou-Chuan Shih
    • 1
  • Tsang-En Wang
    • 1
  • Yu-Jan Chan
    • 2
  • Chih-Jen Chen
    • 1
  • Wen-Hsiung Chang
    • 1
  1. 1.Department of GastroenterologyMackay Memorial Hospital and Mackay Medicine, Nursing and Management CollegeTaipeiTaiwan, Republic of China
  2. 2.Department of PathologyMackay Memorial HospitalTaipeiTaiwan, Republic of China

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