Digestive Diseases and Sciences

, Volume 53, Issue 7, pp 1818–1823 | Cite as

Evaluation of Gastric Cancer Risk Using Topography of Histological Gastritis: A Large-scaled Cross-sectional Study

  • Shinobu Imagawa
  • Masaharu Yoshihara
  • Masanori ItoEmail author
  • Shigeto Yoshida
  • Yoshihiro Wada
  • Masana Tatsugami
  • Akemi Takamura
  • Shinji Tanaka
  • Ken Haruma
  • Kazuaki Chayama
Original Paper


We evaluated the topography of histological gastritis, which may be risk factors for gastric cancer (GCa). A total of 530 Helicobacter pylori-positive patients underwent diagnostic upper-gastrointestinal endoscopy. Biopsy specimens were obtained from the gastric antrum and body to assess the grade of gastritis. Subjects were divided into four groups by the topography of active gastritis (antrum predominant gastritis, AP; pan-gastritis with or without corpus atrophy, Pan-1 and Pan-2; and corpus predominant gastritis, CP). A higher prevalence of GCa followed the order of Pan 2→CP→Pan 1→AP. The age of patients decreased in the same order. When we set Pan 2 and CP as a high-risk group, the sensitivity and specificity for GCa detection were 77.3 and 54.7%, which were superior to the serum criteria using pepsinogens. These suggest that topography of histologic gastritis is an important marker to identify the high-risk group.


Gastritis Updated Sydney system Pepsinogen Gastric cancer 



We thank Ms. Nao Kubota (Hiroshima University, Japan) for the excellent assistance in the production of the database used in this study. This study was supported by grant from Tsuchiya Research Foundation.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Shinobu Imagawa
    • 1
  • Masaharu Yoshihara
    • 2
  • Masanori Ito
    • 1
    Email author
  • Shigeto Yoshida
    • 3
  • Yoshihiro Wada
    • 1
  • Masana Tatsugami
    • 1
  • Akemi Takamura
    • 1
  • Shinji Tanaka
    • 3
  • Ken Haruma
    • 4
  • Kazuaki Chayama
    • 1
  1. 1.Department of Medicine and Molecular Science, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Health Service CenterHiroshima UniversityHigashi-HiroshimaJapan
  3. 3.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  4. 4.Division of Gastroenterology, Department of Internal MedicineKawasaki Medical SchoolKurashikiJapan

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