Digestive Diseases and Sciences

, Volume 52, Issue 10, pp 2821–2825 | Cite as

Helicobacter pylori Infection and Severity of Reflux-Induced Esophageal Disease in a Cohort of Patients with Columnar-Lined Esophagus

  • James R. Ramus
  • Piers A. C. Gatenby
  • Christine P. J. Caygill
  • Anthony Watson
Original Paper


The relationship between Helicobacter pylori infection and reflux-induced esophageal diseased is controversial. We examined esophageal disease severity in patients with columnar-lined esophagus and compared results between patients with and without Helicobacter pylori infection. Medical records of 1000 patients diagnosed with columnar-lined esophagus were examined. Endoscopic and histological findings of reflux-induced esophageal disease were compared between H. pylori-positive and H. pylori-negative patients. Four hundred twenty-nine patients (42.9%) showed evidence of H. pylori status, of whom 239 (55.7%) were positive and 190 (44.3%) negative. There were no significant differences in length of columnar-lined segment (= 0.305), frequency of associated esophagitis (= 0.583), or presence of gastroduodenal inflammation (= 0.335, = 0.131) between the two groups. Histological grade of esophageal disease severity was similar between them, with no statistically significant differences (= 0.231).

We conclude that in patients with established columnar-lined esophagus, there appears to be no difference in severity of reflux-induced esophageal disease between those with and those without H. pylori infection.


Esophagus Barrett’s Helicobacter pylori Dysplasia Eradication 


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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • James R. Ramus
    • 1
    • 2
  • Piers A. C. Gatenby
    • 1
  • Christine P. J. Caygill
    • 1
  • Anthony Watson
    • 1
  1. 1.UK National Barrett’s Esophagus RegistryUniversity Department of SurgeryLondonUK
  2. 2.BucksUK

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