Methylphenidate-Induced Autoimmune Hepatitis
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Autoimmune hepatitis (AIH) is a chronic necroinflammatory disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level . The pathogenesis is proposed to result from a genetically predisposed host being exposed to an environmental agent that triggers an autoimmune process directed at liver antigens causing continued inflammation that results in fibrosis and often cirrhosis . The diagnosis is characterized by serologic markers such as antinuclear antibodies (ANAs), anti-smooth muscle antibody (anti-SMA), antiactin antibody, anti-liver/kidney microsomal antibody (anti-LKMA), and elevated serum globulins, most notably immunoglobulin G (IgG) . Anti-inflammatory/immunosuppressive therapy is effective, with an initial remission rate of 80%, with prognosis inversely proportional to histologic severity of disease .
Many pharmacological agents have been suspected as triggering agents for AIH including methyldopa, nitrofurantoin,...
KeywordsAutoimmune hepatitis Methylphenidate Liver transplantation
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