Drug-Induced Liver Injury: Review Article
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Drug-induced liver injury (DILI) is a term that describes abnormalities in liver function tests (LFTs) related to medication intake. DILI, a subtype of hepatotoxicity, does not include hepatic injuries related to nonmedicinal compounds, including herbal, complementary, and alternative medicines [1, 2].
DILI accounts for roughly 0.1% to 3% of hospital admissions, 600 liver transplantations, and 120 deaths from liver failure in the United States each year [3, 4, 5, 6]. It is the Number 1 cause of death from acute liver failure in the country , and the most frequent cause of medication withdrawal from the market .
The liver is the central organ in the metabolism and detoxification of drugs and toxins. Consequently, drugs affect the liver more frequently than any other organ and place the liver at increased risk for toxic damage . After absorption by the intestines, drugs reach the liver via the portal system. In the hepatocytes, these chemicals undergo complex metabolic...
KeywordsDrug-induced liver injury Hepatotoxicity
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