Digestive Diseases and Sciences

, Volume 52, Issue 7, pp 1595–1612 | Cite as

Zinc and the Liver: An Active Interaction

  • Ioannis Stamoulis
  • Grigorios Kouraklis
  • Stamatios Theocharis
Review article

Abstract

Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver function. Decreased zinc levels have been implicated in both acute and chronic liver disease states, and zinc deficiency has been implicated in the pathogenesis of liver diseases. Zinc supplementation offers protection in experimental animal models of acute and chronic liver injury, but these hepatoprotective properties have not been fully elucidated. In the present review, data on zinc homeostasis, its implication in the pathogenesis of liver diseases, and its effect on acute and chronic liver diseases are presented. It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined.

Keywords

Zinc Liver Injury Acute Chronic Hepatocellular carcinoma 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Ioannis Stamoulis
    • 1
    • 2
  • Grigorios Kouraklis
    • 2
  • Stamatios Theocharis
    • 1
  1. 1.Department of Forensic Medicine and ToxicologyUniversity of Athens, Medical SchoolAthensGreece
  2. 2.2nd Department of Propedeutic SurgeryLaikon General Hospital, University of Athens, Medical SchoolAthensGreece

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