Mucormycosis Presenting as Recurrent Gastric Perforation in a Patient with Crohn’s Disease on Glucocorticoid, 6-Mercaptopurine, and Infliximab Therapy
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Mucormycosis is a rare opportunistic infection caused by fungi from the order Mucorales, which comprises 6 families that can cause varying infectious syndromes . Rhizopus species is the most common organism implicated, but infections have been described with other fungi of the family Mucorales including absidia, mucor, rhizomucor, and cunninghamella [1, 2, 3]. Mucormycosis can present in a variety of anatomic locations including rhinocerebral, pulmonary, cutaneous, gastrointestinal, and disseminated disease depending on underlying host characteristics . The infection was previously rare, with 1 study estimating an incidence of mucormycosis of 1.7 cases per million people per year, although it has been increasing in incidence in recent years [4, 5, 6].
We report a case of gastrointestinal mucormycosis that presented as recurrent gastric perforation in a patient with Crohn’s disease (CD) being treated with corticosteroids, 6-mercaptopurine (6 MP), and infliximab. This is the first...
KeywordsMucormycosis Crohn’s disease Gastric perforation Glucocorticoids 6-Mercaptopurine Infliximab
This case is being reported with full approval of the Cedars-Sinai Medical Center Institutional Review Board.
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