Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2078–2081 | Cite as

Mucormycosis Presenting as Recurrent Gastric Perforation in a Patient with Crohn’s Disease on Glucocorticoid, 6-Mercaptopurine, and Infliximab Therapy

Original Article

Keywords

Mucormycosis Crohn’s disease Gastric perforation Glucocorticoids 6-Mercaptopurine Infliximab 

References

  1. 1.
    Spellberg B, Edwards J, Jr, Ibrahim A (2005) Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 18:556–569PubMedCrossRefGoogle Scholar
  2. 2.
    Spellberg B, Ibrahim A (2005) Gastric mucormycosis: a nosocomial problem. Gastroenterol Hepatol 1:129–130Google Scholar
  3. 3.
    Mitre MC, Mitre RJ, Atkinson DP, Adurty R, Nathan G, Veynovich B (2005) Invasive Gastric Mucormycosis. Gastroenterol Hepatol 1:128–129Google Scholar
  4. 4.
    Rees JR, Pinner RW, Hajjeh RA, Brandt ME, Reingold AL (1998) The epidemiological features of invasive mycotic infections in the San Francisco Bay area, 1992–1993: results of population-based laboratory active surveillance. Clin Infect Dis 27:1138–1147PubMedGoogle Scholar
  5. 5.
    Marr KA, Carter RA, Crippa F, Wald A, Corey L (2002) Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis 34:909–917PubMedCrossRefGoogle Scholar
  6. 6.
    Kontoyiannis DP, Wessel VC, Bodey GP, Rolston KV (2000) Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis 30:851–856PubMedCrossRefGoogle Scholar
  7. 7.
    Chinn RY, Diamond RD (1982) Generation of chemotactic factors by Rhizopus oryzae in the presence and absence of serum: relationship to hyphal damage mediated by human neutrophils and effects of hyperglycemia and ketoacidosis. Infect Immun 38:1123–1129PubMedGoogle Scholar
  8. 8.
    Rickerts V, Bohme A, Just-Nubling G (2002) [Risk factor for invasive zygomycosis in patients with hematologic malignancies]. Mycoses 45(suppl)1:27–30Google Scholar
  9. 9.
    Leong KW, Crowley B, White B, Crotty GM, O’Briain DS, Keane C, McCann SR (1997) Cutaneous mucormycosis due to Absidia corymbifera occurring after bone marrow transplantation. Bone Marrow Transplant 19:513–515PubMedCrossRefGoogle Scholar
  10. 10.
    Maertens J, Demuynck H, Verbeken EK, Zachee P, Verhoef GE, Vandenberghe P, Boogaerts MA (1999) Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 24:307–312PubMedCrossRefGoogle Scholar
  11. 11.
    Marchevsky AM, Bottone EJ, Geller SA, Giger DK (1980) The changing spectrum of disease, etiology, and diagnosis of mucormycosis. Hum Pathol 11:457–464PubMedCrossRefGoogle Scholar
  12. 12.
    Martinez EJ, Cancio MR, Sinnott JTt, Vincent AL, Brantley SG (1997) Nonfatal gastric mucormycosis in a renal transplant recipient. South Med J 90:341–344PubMedCrossRefGoogle Scholar
  13. 13.
    Marty FM, Cosimi LA, Baden LR (2004) Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N Engl J Med 350:950–952PubMedCrossRefGoogle Scholar
  14. 14.
    Mazza D, Gugenheim J, Baldini E, Mouiel J (1999) Gastrointestinal mucormycosis and liver transplantation; a case report and review of the literature. Transpl Int 12:297–298PubMedCrossRefGoogle Scholar
  15. 15.
    Morrison VA, McGlave PB (1993) Mucormycosis in the BMT population. Bone Marrow Transplant 11:383–388PubMedGoogle Scholar
  16. 16.
    Nagy-Agren SE, Chu P, Smith GJ, Waskin HA, Altice FL (1995) Zygomycosis (mucormycosis) and HIV infection: report of three cases and review. J Acquir Immune Defic Syndr Hum Retrovirol 10:441–449PubMedGoogle Scholar
  17. 17.
    Boelaert JR, de Locht M, Van Cutsem J, Kerrels V, Cantinieaux B, Verdonck A, VanLanduyt HW, Schneider YJ (1993) Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. J Clin Invest 91:1979–1986PubMedCrossRefGoogle Scholar
  18. 18.
    Moonka D, Lichtenstein GR, Levine MS, Rombeau JL, Furth EE, MacDermott RP (1993) Giant gastric ulcers: an unusual manifestation of Crohn’s disease. Am J Gastroenterol 88:297–299PubMedGoogle Scholar
  19. 19.
    Katz S, Talansky A, Kahn E (1983) Recurrent free perforation in gastroduodenal Crohn’s disease. Am J Gastroenterol 78:722–725PubMedGoogle Scholar
  20. 20.
    Katz S, Schulman N, Levin L (1986) Free perforation in Crohn’s disease: a report of 33 cases and review of literature. Am J Gastroenterol 81:38–43PubMedGoogle Scholar
  21. 21.
    Yamamoto T, Allan RN, Keighley MR (1999) An audit of gastroduodenal Crohn disease: clinicopathologic features and management. Scand J Gastroenterol 34:1019–1024PubMedCrossRefGoogle Scholar
  22. 22.
    Agha FP, Lee HH, Boland CR, Bradley SF (1985) Mucormycoma of the colon: early diagnosis and successful management. AJR Am J Roentgenol 145:739–741PubMedGoogle Scholar
  23. 23.
    Woodward A, McTigue C, Hogg G, Watkins A, Tan H (1992) Mucormycosis of the neonatal gut: a “new” disease or a variant of necrotizing enterocolitis? J Pediatr Surg 27:737–740PubMedCrossRefGoogle Scholar
  24. 24.
    Siu KL, Lee WH (2004) A rare cause of intestinal perforation in an extreme low birth weight infant—gastrointestinal mucormycosis: a case report. J Perinatol 24:319–321PubMedCrossRefGoogle Scholar
  25. 25.
    Suh IW, Park CS, Lee MS, Lee JH, Chang MS, Woo JH, Lee IC, Ryu JS (2000) Hepatic and small bowel mucormycosis after chemotherapy in a patient with acute lymphocytic leukemia. J Korean Med Sci 15:351–354PubMedGoogle Scholar
  26. 26.
    Ibanez R, Serrano-Heranz R, Sanchez-Zaballos I, Carbonero P, Lopez G (1997) Disseminated mucormycosis due to Absidia corymbifera in a patient with inflammatory bowel disease. Clin Microbiol Infect 3:268–270PubMedCrossRefGoogle Scholar
  27. 27.
    Hunter AJ, Bryant RE (2002) Abdominal wall mucormycosis successfully treated with amphotericin and itraconazole. J Infect 44:203–204PubMedCrossRefGoogle Scholar
  28. 28.
    Norden G, Bjorck S, Persson H, Svalander C, Li XG, Edebo L (1991) Cure of zygomycosis caused by a lipase-producing Rhizopus rhizopodiformis strain in a renal transplant patient. Scand J Infect Dis 23:377–382PubMedGoogle Scholar
  29. 29.
    Stevens KM, Newell RC, Bergstrom L (1972) Mucormycosis in a patient receiving azathioprine. Arch Otolaryngol 96:250–251PubMedGoogle Scholar
  30. 30.
    Maravi-Poma E, Rodriguez-Tudela JL, de Jalon JG, Manrique-Larralde A, Torroba L, Urtasun J, Salvador B, Montes M, Mellado E, Rodriguez-Albarran F, Pueyo-Royo A (2004) Outbreak of gastric mucormycosis associated with the use of wooden tongue depressors in critically ill patients. Intensive Care Med 30:724–728PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Cedars-Sinai Medical CenterInflammatory Bowel Disease CenterLos AngelesUSA
  2. 2.Cedars-Sinai Medical CenterDepartment of PathologyLos AngelesUSA

Personalised recommendations