Digestive Diseases and Sciences

, Volume 52, Issue 2, pp 405–410 | Cite as

Serum Ferritin, Vitamin B12, Folate, and Zinc Levels in Children Infected with Helicobacter pylori

  • Mustafa Akcam
  • Sebahat Ozdem
  • Aygen Yilmaz
  • Meral Gultekin
  • Reha Artan
Original Article


We sought to explore the relationship between Helicobacter pylori infection and serum ferritin, vitamin B12, folate, and zinc status among children. Fifty patients aged 5–18 years who underwent upper gastrointestinal endoscopy because of dyspeptic symptoms, were studied, prospectively. Patients were grouped as H. pylori positive (group 1, n=32) or H. pylori negative (group 2, n=18) by histopathologic examination and rapid urease test. Fasting serum ferritin, vitamin B12, folate, and zinc levels of patients were measured. Both groups were indifferent according to age, gender, height standard deviation score (HSDS), and weight standard deviation score (WSDS). Serum ferritin levels were 33±26 and 50±46 ng/mL (P=.098), vitamin B12 levels were 303±135 and 393±166 pg/mL (P=.042), folate levels were 9.64±3.2 and 9.61±2.8 ng/mL (P=.979), and zinc levels were 95±48 and 87±31 μg/dL (P=.538), in groups 1 and 2, respectively. Ferritin levels of 14 (43.8%) patients in group 1 and 6 (33.3%) patients in group 2 were below the normal range (P=.470). Serum vitamin B12 levels of 9 children (28%) in group 1 and 2 children (11%) in group 2 were below the normal range (P=.287). The findings of the present study suggest that H. pylori infection has a negative effect on serum ferritin and vitamin B12 levels in children. This negative effect on vitamin B12 levels is rather marked in contrast to that on ferritin levels. H. pylori infection has no significant effect on serum folate or zinc levels among children.


Helicobacter pylori Child Vitamin B12 Folate Zinc Micronutrient 



The authors thank Kezban Özkalay, Şehriban Karakaya, and Nehime Kara for their help and cooperation; and Dr Hakan Gülkesen for help in statistical analysis. This study was supported by Akdeniz University Research Projects Unit.


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Mustafa Akcam
    • 1
  • Sebahat Ozdem
    • 2
  • Aygen Yilmaz
    • 1
  • Meral Gultekin
    • 3
  • Reha Artan
    • 1
  1. 1.Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and NutritionAkdeniz University, Medical SchoolAntalyaTurkey
  2. 2.Department of Central Lab, Biochemistry UnitAkdeniz University, Medical SchoolAntalyaTurkey
  3. 3.Department of BiochemistryAkdeniz University, Medical SchoolAntalyaTurkey

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