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Digestive Diseases and Sciences

, Volume 52, Issue 1, pp 248–253 | Cite as

Expression of IGFBP2 in Gastric Carcinoma and Relationship With Clinicopathologic Parameters and Cell Proliferation

  • Lihua Zhang
  • Wenbin Huang
  • Jieyu Chen
  • Xiaojun ZhouEmail author
  • Zhenfeng Lu
  • Hangbo Zhou
Original Paper

Abstract

The insulin-like growth factor (IGF) axis is a complex system composed of two mitogenic ligands, IGF-I and IGF-II, two receptors, IGF-IR and IGF-IIR, and six binding proteins, IGFBP1 to IGFBP6. The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. The present study evaluated the correlation between IGFBP2 expression and clinicopathologic parameters and cell proloferation in cancer by using surgically resected tissue specimens from 97 patients with gastric carcinoma treated at our hospital. Immunohistochemical staining was performed using IGFBP2 and Ki-67 monoclonal antibody. An obvious difference existed in the IGFBP2 expression between carcinomas and normal mucosa. Correlation between IGFBP2 expression and the depth of penetration, lymph node metastasis, and clinical stage were observed. There was positive correlation between IGFBP2 expression and Ki-67 expression. We conclude that IGFBP2 may be involved in carcinogenesis and progression of gastric carcinoma by promoting cell proliferation.

Keywords

Insulin-like growth factor binding protein Gastric carcinoma Ki-67 Cell proliferation 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Lihua Zhang
    • 1
  • Wenbin Huang
    • 1
  • Jieyu Chen
    • 1
  • Xiaojun Zhou
    • 1
    Email author
  • Zhenfeng Lu
    • 1
  • Hangbo Zhou
    • 1
  1. 1.Department of Pathology, Jinling HospitalClinical School of Medical College of Nanjing UniversityNanjingP.R. China

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