Digestive Diseases and Sciences

, Volume 51, Issue 5, pp 1016–1019

Celiac Disease Prevalence in Brazilian Dilated Cardiomyopathy Patients

  • Ricardo Schmit T De Bem
  • Shirley Ramos Da Ro Sa Utiyama
  • Renato Mitsunori Nisihara
  • Jerônimo Antônio fortunato
  • josuÉ Augusto Tondo
  • Eliane Ribeiro Carmes
  • Raquel Almada E. Souza
  • Julio CÉsar Pisani
  • Heda Maria Barska Dos Santos Amarante
Article

DOI: 10.1007/s10620-006-9337-4

Cite this article as:
De Bem, R.S.T., Da Ro Sa Utiyama, S.R., Nisihara, R.M. et al. Dig Dis Sci (2006) 51: 1016. doi:10.1007/s10620-006-9337-4

Abstract

Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti–h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti–h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.

Key Words

celiac disease cardiomyopathy anti-tissue transglutaminase antibody anti-endomisial antibody 

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Ricardo Schmit T De Bem
    • 1
    • 4
  • Shirley Ramos Da Ro Sa Utiyama
    • 2
  • Renato Mitsunori Nisihara
    • 2
  • Jerônimo Antônio fortunato
    • 3
  • josuÉ Augusto Tondo
    • 3
  • Eliane Ribeiro Carmes
    • 1
  • Raquel Almada E. Souza
    • 1
  • Julio CÉsar Pisani
    • 1
  • Heda Maria Barska Dos Santos Amarante
    • 1
  1. 1.Service of Gastroenterology and Digestive Endoscopy, Clinical HospitalFederal University of ParanáCuritibaBrazil
  2. 2.Laboratory of Immunopathology, Clinical HospitalFederal University of ParanáCuritibaBrazil
  3. 3.Cardiac Transplant Unit, Clinical HospitalFederal University of ParanáCuritibaBrazil
  4. 4.CuritibaBrazil

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