Digestive Diseases and Sciences

, Volume 52, Issue 4, pp 967–972 | Cite as

Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

  • Sebahat Ozdem
  • Mustafa Akcam
  • Aygen Yilmaz
  • Meral Gultekin
  • Reha Artan
Original Paper


We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8±3 years). Serum levels of intact parathyroid hormone, ß-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (−) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(−) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.


Bone markers Children Ferritin Helicobacter pylori Osteoporosis Vitamin B12 



This study was supported by the Akdeniz University Research Projects Unit. The authors thank Dr. Levent Donmez for his contribution in data analysis.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Sebahat Ozdem
    • 1
  • Mustafa Akcam
    • 2
  • Aygen Yilmaz
    • 2
  • Meral Gultekin
    • 3
  • Reha Artan
    • 2
  1. 1.Central LaboratoryClinical Biochemistry Unit, Akdeniz University, Medical FacultyAntalyaTurkey
  2. 2.Department of PediatricsDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical FacultyAntalyaTurkey
  3. 3.Department of MicrobiologyAkdeniz University, Medical FacultyAntalyaTurkey

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