Digestive Diseases and Sciences

, Volume 52, Issue 9, pp 2438–2443 | Cite as

Hepatitis Associated with Aplastic Anemia: Do CD8(+) Kupffer Cells Have a Role in the Pathogenesis?

  • Cem CengizEmail author
  • Nesrin Turhan
  • O. Faruk Yolcu
  • Sevinc Yılmaz
Case Report


Hepatitis-associated aplastic anemia (HAAA), first described by Lorenz and Quaiser in 1955 [1], is a rare phenomenon which usually affects adolescents and young men [2] and is more common in the East than in the West [3, 4, 5]. It represents a minor proportion of all aplastic anemia cases [6] and may occur in 28% of young adults after liver transplantation for non-A, non-B hepatitis [7]. Although a limited number of aplastic anemia cases have been reported in association with hepatitis A, B, and G, parvovirus B19, Epstein-Barr virus (EBV), transfusion transmitted virus (TTV), and echovirus [8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20], the causative agent in most of the cases still remains unknown [21, 23]. Patients typically develop severe aplastic anemia 2 to 3 months after an episode of acute hepatitis. Aplastic anemia is always fatal if untreated [2, 11] and the hepatitis associated with this may be mild and transient [2, 22], fulminant [7, 23], or chronic [2]....


Hepatitis Aplastic anemia Cytotoxic T cells Kupffer cells Immunohistochemistry Immunosuppressive therapy 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Cem Cengiz
    • 1
    Email author
  • Nesrin Turhan
    • 2
  • O. Faruk Yolcu
    • 1
  • Sevinc Yılmaz
    • 3
  1. 1.Department of GastroenterologyTurkiye Yuksek Ihtisas HastanesiEmekTurkey
  2. 2.Department of PathologyTurkiye Yuksek Ihtisas HastanesiAnkaraTurkey
  3. 3.Department of HematologyTurkiye Yuksek Ihtisas HastanesiAnkaraTurkey

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