Digestive Diseases and Sciences

, Volume 52, Issue 2, pp 558–560 | Cite as

A Case of Fatal Necrotizing Pancreatitis: Complication of Hydrochlorothiazide and Lisinopril Therapy

  • Sareen Bedrossian
  • Bobbak VahidEmail author

We report a case of fatal necrotizing pancreatitis associated with hydrochlorothiazide and lisinopril therapy. A 49-year-old man who presented with 2 days of abdominal pain and vomiting was found to have severe pancreatitis. The patient denied any alcohol use. In addition, abdominal ultrasound examinations showed no evidence of cholelithiasis or bile duct dilations. Review of his medication history with the family revealed that he was being treated with hydrochlorothiazide and lisinopril for hypertension. An exploratory laparotomy was performed and revealed no common bile duct stones. Unfortunately, the patient's hospital course was complicated with multiple organ failure, which resulted in death. To the best of our knowledge, there are only 3 other reported cases of hydrochlorothiazide-induced necrotizing pancreatitis reported in the literature.

Case report

A 49-year-old man presented to the emergency department (ED) with a 2-day history of severe, diffuse abdominal pain and vomiting....


Pancreatitis Acute Pancreatitis Common Bile Duct Hydrochlorothiazide Thiazide 
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Copyright information

© Springer Science + Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Department of PharmacyThomas Jefferson University HospitalPhiladelphiaUSA
  2. 2.Department of Pulmonary and Critical Care MedicineThomas Jefferson University HospitalPhiladelphiaUSA

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