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Digestive Diseases and Sciences

, Volume 51, Issue 11, pp 2094–2101 | Cite as

Rose Hip and Lactobacillus plantarum DSM 9843 Reduce Ischemia/Reperfusion Injury in the Mouse Colon

  • Å. Håkansson
  • C. Stene
  • A. Mihaescu
  • G. Molin
  • S. Ahrné
  • H. Thorlacius
  • B. Jeppsson
Original Paper

Abstract

Ischaemia/reperfusion (I/R) of the colon is an inflammatory condition that leads to tissue injury where reactive oxygen species play a central role. Rose hip is rich in biologically active polyphenols with antioxidative properties, which may be important in prevention of lipid peroxidation. L. plantarum DSM 9843 possesses enzymatic activity towards polyphenols. The objective of this study was to define the effect of oral administration of L. plantarum and rose hip in I/R injury. Administration of rose hip and L. plantarum significantly decreased MDA levels in caecum tissue and Enterobacteriaceae counts in caecum stool. A positive correlation between MDA levels and Enterobacteriaceae counts was found. The results support a synergistic/additive role of rose hip and L. plantarum in reducing lipid peroxidation. Therefore rose hip and L. plantarum may be used as a pretreatment to tissue injuries, e.g. colonic surgery, organ transplantation and vascular surgery.

Keywords

Ischaemia Reperfusion Rose hip Polyphenols Lactobacilli 

Notes

Acknowledgements

Susanne Eiswohld and Diya Adawi are thanked for technical support; Jonas Björk, biostatistician, Competence Center for Clinical Research, Lund University Hospital for statistical analysis and Virgil Gadaleanu, Dept. of Pathology, Malmö University Hospital, for histological examination, are all gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Å. Håkansson
    • 1
  • C. Stene
    • 2
  • A. Mihaescu
    • 2
  • G. Molin
    • 1
  • S. Ahrné
    • 1
  • H. Thorlacius
    • 2
  • B. Jeppsson
    • 2
  1. 1.Food Hygiene, Department of Food Technology, Engineering and NutritionLund UniversityLundSweden
  2. 2.Department of SurgeryMalmö University Hospital, Lund UniversityMalmöSweden

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