Digestive Diseases and Sciences

, Volume 52, Issue 8, pp 1987–1994

Significance of Enhanced Expression of Nitric Oxide Syntheses in Splenic Sinus Lining Cells in Altered Portal Hemodynamics of Idiopathic Portal Hypertension

  • Yasunori Sato
  • Seiko Sawada
  • Kazuto Kozaka
  • Kenichi Harada
  • Motoko Sasaki
  • Osamu Matsui
  • Yasuni Nakanuma
Original Paper

DOI: 10.1007/s10620-006-9146-9

Cite this article as:
Sato, Y., Sawada, S., Kozaka, K. et al. Dig Dis Sci (2007) 52: 1987. doi:10.1007/s10620-006-9146-9

Abstract

Idiopathic portal hypertension (IPH) is characterized by noncirrhotic portal hypertension due mainly to increased intrahepatic, presinusoidal resistance to portal blood flow. Marked splenomegaly is always seen in IPH. To clarify the pathogenetic significance of splenomegaly, immunohistochemical expression of inducible nitric oxide synthese (iNOS), endothelial NOS (eNOS), and endothelin-1 (ET-1) in spleens from patients with IPH was examined. Sinus lining cells of IPH spleens showed diffuse and strong expression of iNOS and eNOS. Sinus lining cells of spleens from patients with liver cirrhosis (LC) also showed positive signals for iNOS and eNOS, but the staining intensity was significantly weak. ET-1 was detectable in only a few mononuclear leukocytes in the red pulp of both IPH and LC spleens. These results suggest that NO liberated in spleen, rather than ET-1, is responsible for the dilatation of splenic sinuses, leading to splenomegaly, and thereby contributes to portal hypertension in IPH.

Keywords

Idiopathic portal hypertension Spleen Nitric oxide Endothelin 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Yasunori Sato
    • 1
  • Seiko Sawada
    • 1
  • Kazuto Kozaka
    • 2
  • Kenichi Harada
    • 1
  • Motoko Sasaki
    • 1
  • Osamu Matsui
    • 2
  • Yasuni Nakanuma
    • 1
  1. 1.Department of Human PathologyKanazawa University Graduate School of MedicineKanazawaJapanUSA
  2. 2.Department of RadiologyKanazawa University Graduate School of MedicineKanazawaJapan

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