Digestive Diseases and Sciences

, Volume 51, Issue 5, pp 858–863 | Cite as

Presenting Symptoms of Nonerosive and Erosive Esophagitis in Pediatric Patients

  • Sandeep K. Gupta
  • Eric Hassall
  • Yi-Lin Chiu
  • Fouad Amer
  • Melvin B. Heyman
Original Paper


Children and adolescents with symptomatic gastroesophageal reflux disease (GERD) and erosive esophagitis (EE) of grade ≥2 (n=45) or nonerosive esophagitis (NEE) (n=45) were assessed to determine the relationship between presenting symptoms, esophagitis severity, and patient age. Overall, regurgitation/vomiting, abdominal pain, and cough were the most frequent symptoms. The prevalence and severity of anorexia/feed refusal was significantly greater in EE versus NEE children; this symptom was also significantly more prevalent in younger (1–5 years) children (both NEE and EE groups) compared to older children. Cough was significantly less severe in NEE adolescents than in younger children. Cough, anorexia/feed refusal, and regurgitation/vomiting were more severe and heartburn was less severe in EE children aged 1–5 years compared with older patients. In conclusion, GERD in children manifests differently than that in adults and symptoms vary with patient age. Symptoms were not predictive of presence or lack of mucosal damage.


Children Adolescents Gastroesophageal reflux disease Nonerosive reflux disease Erosive esophagitis Feeding problems Cough Abdominal pain 



This study was supported by a grant from TAP Pharmaceutical Products Inc., Lake Forest, Illinois (TAP Studies: M97-808 & M97-640). M.B.H. is supported by NIH Grant DK 060617. We thank Susan Ruffalo, PharmD, of MedWrite, Inc., for consolidating and incorporating the authors’ comments and for creating the figures.

These data were presented at the Annual Meeting of the American Gastroenterological Association 2001.

We thank the children and parents for their participation in this study and the study nurses/coordinators for their diligent efforts. Participating centers included (L. Book) University of Utah, Salt Lake City, Utah; (D, Gremse) University of South Alabama, Mobile, Alabama; (T. Gunasekaran) Lutheran General Children's Hospital, Park Ridge, Illinois; (M.B. Heyman) University of California—San Francisco, San Francisco, California; (R. Kane, III) Cardinal Glennon Children's Hospital, St. Louis, Missouri; (R. Steffen) Cleveland Clinic Foundation, Cleveland, Ohio; (V. Tolia) Children's Hospital of Michigan, Detroit, Michigan; (H. Winter) Mass General Hospital for Children, Boston, Massachusetts; (G. Ferry) Texas Children's Hospital, Houston, Texas; (S. Gupta) Riley Hospital for Children, Indianapolis, Indiana; (S. Czinn) Rainbow Babies and Children's Hospital, Cleveland, Ohio; and (R. Torres-Pinedo) Digestive Disease Research Institute, Oklahoma City, Oklahoma.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Sandeep K. Gupta
    • 1
  • Eric Hassall
    • 2
  • Yi-Lin Chiu
    • 3
  • Fouad Amer
    • 4
  • Melvin B. Heyman
    • 5
  1. 1.Riley Hospital for ChildrenIndianapolisUSA
  2. 2.British Columbia Children's HospitalUniversity of British ColumbiaVancouverColumbia
  3. 3.Abbott LaboratoriesIllinoisUSA
  4. 4.TAP Pharmaceutical Products Inc.Lake ForestUSA
  5. 5.UCSF Children's HospitalUniversity of California, San FranciscoSan FranciscoUSA

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