Digestive Diseases and Sciences

, Volume 51, Issue 2, pp 370–373

Association Between Helicobacter pylori Infection and Cirrhosis in Patients with Chronic Hepatitis C Virus

  • Dulciene Maria Magalhães Queiroz
  • Andreia Maria Camargos Rocha
  • Gifone Aguiar Rocha
  • Sarah Maria Singulano Cinque
  • Adriana Gonçalves Oliveira
  • Alicia Godoy
  • Hugo Tanno
Liver

Abstract

We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20–78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06–5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00–1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.

Key Words

hepatitis C virus cirrhosis pathogenesis Helicobacter pylori 

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Dulciene Maria Magalhães Queiroz
    • 1
    • 4
  • Andreia Maria Camargos Rocha
    • 1
  • Gifone Aguiar Rocha
    • 1
  • Sarah Maria Singulano Cinque
    • 1
  • Adriana Gonçalves Oliveira
    • 2
  • Alicia Godoy
    • 3
  • Hugo Tanno
    • 3
  1. 1.Laboratory of Research in Bacteriology, Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte
  2. 2.Faculdade de Medicina do Triângulo MineiroBrasil
  3. 3.Servicio de Gastroenterologia del Hospital CentenarioUniversidad Nacional de RosarioRosarioArgentina
  4. 4.Faculdade de Medicina da Universidade Federal de Minas GeraisBelo HorizonteArgentina

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