Digestive Diseases and Sciences

, Volume 51, Issue 1, pp 99–104

Association Between Gastric Atrophy and Helicobacter pylori Infection in Japanese Children: A Retrospective Multicenter Study

  • Seiichi Kato
  • Shigemi Nakajima
  • Yoshikazu Nishino
  • Kyoko Ozawa
  • Takanori Minoura
  • Mutsuko Konno
  • Shunichi Maisawa
  • Shigeru Toyoda
  • Norikazu Yoshimura
  • Ajula Vaid
  • Robert M. Genta
Article

DOI: 10.1007/s10620-006-3091-5

Cite this article as:
Kato, S., Nakajima, S., Nishino, Y. et al. Dig Dis Sci (2006) 51: 99. doi:10.1007/s10620-006-3091-5

Abstract

The purpose of this study was to determine whether Helicobacter pylori infection and mucosal inflammation result in gastric atrophy in Japanese children. A total of 196 patients ages 1–16 years were retrospectively studied: 131 patients were infected with H. pylori and 65 patients were uninfected. Antral (n = 196) and corpus biopsy specimens (n = 70) were investigated based on the Updated Sydney system. In both the antrum and corpus, H. pylori-infected patients showed significantly higher degrees of inflammation and activity of gastritis, compared with noninfected patients. The prevalence of grade 2 or 3 atrophy in the antrum was 10.7% in H. pylori-infected patients and 0% in the noninfected patients (P < .01) and in corpus 4.3% and 0%, respectively (P = .20). The frequency of intestinal metaplasia in the 2 study groups was 4.6% and 4.6% in the antrum and 0% and 4.2% in the corpus, respectively. Among H. pylori-infected patients, the antrum showed significantly higher degrees of H. pylori density, inflammation and activity of gastritis, and atrophy than the corpus. In the antrum, atrophy was significantly correlated with activity, whereas in the corpus, atrophy correlated with H. pylori density, inflammation, and activity. H. pylori-induced gastric inflammation can cause atrophy in Japanese children, predominantly in the antrum. It remains to be determined whether H. pylori-infected children with gastric atrophy are at increased risk for gastric cancer.

Key Words

atrophy child gastritis Helicobacter pylori intestinal metaplasia 

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Seiichi Kato
    • 1
    • 10
  • Shigemi Nakajima
    • 2
  • Yoshikazu Nishino
    • 3
  • Kyoko Ozawa
    • 1
  • Takanori Minoura
    • 1
  • Mutsuko Konno
    • 4
  • Shunichi Maisawa
    • 5
  • Shigeru Toyoda
    • 6
  • Norikazu Yoshimura
    • 7
  • Ajula Vaid
    • 8
  • Robert M. Genta
    • 9
  1. 1.Department of PediatricsTohoku University School of MedicineSendaiJapan
  2. 2.Department of GastroenterologySocial Insurance Shiga HospitalOtsuJapan
  3. 3.Departments of Public HealthTohoku University School of MedicineSendaiJapan
  4. 4.Sapporo Kohsei General HospitalSapporoJapan
  5. 5.Morioka Children's HospitalMoriokaJapan
  6. 6.Kanagawa Prefecture Midwives and Nurses Training HospitalYokohamaJapan
  7. 7.Osaka Medical Center for Maternal and Child HealthOsakaJapan
  8. 8.Department of PathologyVeterans Affairs Medical CenterHouston
  9. 9.Division de Pathologie CliniqueHopital Universitaire de GeneveGeneveSwitzerland
  10. 10.The Hershey Medical CenterHersheyUSA

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