Digestive Diseases and Sciences

, Volume 51, Issue 9, pp 1582–1588 | Cite as

Helicobacter pylori Infection Is the Major Risk Factor for Gastric Inflammation in the Cardia

  • Yasuo Egi
  • Sunjin Kim
  • Masanori ItoEmail author
  • Shinji Tanaka
  • Masaharu Yoshihara
  • Ken Haruma
  • Kazuaki Chayama
Original Paper


We attempted to clarify the pathogenesis of gastric inflammation in the cardia. Eighty Japanese participated in this study. Biopsy specimens of the gastric antrum, corpus, and cardia (1 cm from the squamocolumnar junction) were obtained, and histological gastritis was evaluated. Cardiac inflammation was also evaluated using magnifying gastroscopy. We examined Helicobacter pylori infection, gastric juice pH/bile acid (BA), serum pepsinogen and gastrin levels, gastroesophageal reflux disease (GERD), and habitual smoking and assessed the relations between these factors and cardiac inflammation. The prevalence of H. pylori infection was statistically higher in patients with cardiac inflammation than in those without inflammation (P < 0.05). The relationship was also demonstrated by magnifying gastroscopy. Cardiac inflammation was linked to low acid output but not linked to the BA concentration or habitual smoking. Cardiac inflammation was more pronounced in patients without GERD. These results suggest that H. pylori is a major risk factor for cardiac inflammation in the Japanese.


Atrophic gastritis Carditis Gastroesophageal reflux disease (GERD) Magnifying endoscope Helicobacter pylori 



We thank Ms. Nao Kubota (Hiroshima University) for her excellent assistance in the production of the database used in this study.


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Yasuo Egi
    • 1
  • Sunjin Kim
    • 1
  • Masanori Ito
    • 1
    • 5
    Email author
  • Shinji Tanaka
    • 2
  • Masaharu Yoshihara
    • 3
  • Ken Haruma
    • 4
  • Kazuaki Chayama
    • 1
  1. 1.Department of Medicine and Molecular ScienceGraduate School of Biomedical Sciences, Hiroshima UniversityHiroshimaJapan
  2. 2.Department of EndoscopyHiroshima University HospitalHiroshimaJapan
  3. 3.Health Service CenterHiroshima UniversityHigashi-HiroshimaJapan
  4. 4.Division of GastroenterologyDepartment of Internal Medicine, Kawasaki Medical SchoolKurashikiJapan
  5. 5.Department of Medicine and Molecular ScienceHiroshima UniversityHiroshimaJapan

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