Digestive Diseases and Sciences

, Volume 51, Issue 5, pp 952–955 | Cite as

Hepatocellular Carcinoma Occurring in a Patient with Crohn’s Disease Treated with Both Azathioprine and Infliximab

  • Shawn C. Chen
  • Oscar W. Cummings
  • Michael P. Hartley
  • Carol A. Filomena
  • Won Kyoo ChoEmail author
Original Paper


Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis. All reported cases of hepatocellular carcinoma in association with Crohn’s disease involve patients treated previously with azathioprine or both azathioprine and steroids. However, hepatocellular carcinoma associated with the use of azathioprine and infliximab has not been reported. In this report, we describe an unusual case of hepatocellular carcinoma and focal hepatic glycogenosis (FHG) occurring in a non-cirrhotic Crohn’s disease patient who has been treated with both azathioprine and infliximab.

Key Words

Hepatocellular carcinoma Infliximab Azathioprine Crohn’s disease Focal hepatic glycogenosis 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Shawn C. Chen
    • 1
  • Oscar W. Cummings
    • 2
  • Michael P. Hartley
    • 3
  • Carol A. Filomena
    • 2
  • Won Kyoo Cho
    • 3
    • 4
    Email author
  1. 1.Departments of MedicineIndiana University School of MedicineIndianapolisUSA
  2. 2.Departments of PathologyIndiana University School of MedicineIndianapolisUSA
  3. 3.Division of GastroenterologyIndiana University School of MedicineIndianapolisUSA
  4. 4.Department of MedicineIndiana University School of Medicine and Roudebush VA Medical CenterIndianapolisUSA

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