Advertisement

Digestive Diseases and Sciences

, Volume 51, Issue 5, pp 952–955 | Cite as

Hepatocellular Carcinoma Occurring in a Patient with Crohn’s Disease Treated with Both Azathioprine and Infliximab

  • Shawn C. Chen
  • Oscar W. Cummings
  • Michael P. Hartley
  • Carol A. Filomena
  • Won Kyoo ChoEmail author
Original Paper

Abstract

Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis. All reported cases of hepatocellular carcinoma in association with Crohn’s disease involve patients treated previously with azathioprine or both azathioprine and steroids. However, hepatocellular carcinoma associated with the use of azathioprine and infliximab has not been reported. In this report, we describe an unusual case of hepatocellular carcinoma and focal hepatic glycogenosis (FHG) occurring in a non-cirrhotic Crohn’s disease patient who has been treated with both azathioprine and infliximab.

Key Words

Hepatocellular carcinoma Infliximab Azathioprine Crohn’s disease Focal hepatic glycogenosis 

References

  1. 1.
    Lee FL, Murray SM, Prior J, Shreeve DR (1983) Primary liver cell cancer occurring in association with Crohn’s disease treated with prednisolone and azathioprine. Hepatogastroenterology 30:188PubMedGoogle Scholar
  2. 2.
    Cattan S, Wendum D, Chazouilleres O, Schmitz J, Gendre JP (2000) Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. Hum Pathol 31:874–876PubMedCrossRefGoogle Scholar
  3. 3.
    Gruber S, Dehner LP, Simmons RL (1987) De novo hepatocellular carcinoma without chronic liver disease but with 17 years of azathioprine immunosuppression. Transplantation 43:597–600PubMedCrossRefGoogle Scholar
  4. 4.
    Saeian K, Franco J, Komorowski RA, Adams MB (1999) Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series. Liver Transpl Surg 5:46–49PubMedCrossRefGoogle Scholar
  5. 5.
    Borum ML (2001) Unusual development of hepatocellular carcinoma in a patient with Crohn’s disease. Dig Dis Sci 46:2199–2200PubMedCrossRefGoogle Scholar
  6. 6.
    Russmann S, Zimmermann A, Krähenbühl S, Kern B, Reichen J (2001) Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis. Eur J Gastroenterol Hepatol 13:287–290PubMedCrossRefGoogle Scholar
  7. 7.
    MacSween RNM, Burt AD, Portmann BC, Ishak KG, Scheuer PJ, Anthony PP (2002) Pathology of liver, 4th ed. Churchchill Livingstone, New YorkGoogle Scholar
  8. 8.
    Esser AC, Abril A, Fayne S, Doyle JA (2004) Acute development of multiple keratoacanthomas and squamous cell carcinomas after treatment with infliximab. J Am Acad Dermatol 50:S75–S77PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Shawn C. Chen
    • 1
  • Oscar W. Cummings
    • 2
  • Michael P. Hartley
    • 3
  • Carol A. Filomena
    • 2
  • Won Kyoo Cho
    • 3
    • 4
    Email author
  1. 1.Departments of MedicineIndiana University School of MedicineIndianapolisUSA
  2. 2.Departments of PathologyIndiana University School of MedicineIndianapolisUSA
  3. 3.Division of GastroenterologyIndiana University School of MedicineIndianapolisUSA
  4. 4.Department of MedicineIndiana University School of Medicine and Roudebush VA Medical CenterIndianapolisUSA

Personalised recommendations