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Digestive Diseases and Sciences

, Volume 50, Issue 11, pp 2191–2193 | Cite as

Curcumin Therapy in Inflammatory Bowel Disease: A Pilot Study

  • Peter R. Holt
  • Seymour Katz
  • Robert Kirshoff
Article

Abstract

Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.

Key Words

curcumin ulcerative proctitis Crohn's disease inflammatory bowel disease 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Peter R. Holt
    • 1
    • 3
  • Seymour Katz
    • 2
  • Robert Kirshoff
    • 2
  1. 1.St. Luke's Roosevelt Hospital CenterColumbia University and Strang Cancer Center Research LaboratoryNew York
  2. 2.Long Island Clinical Research AssociatesGreat NeckUSA
  3. 3.New YorkNew YorkUSA

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