Digestive Diseases and Sciences

, Volume 50, Issue 10, pp 1889–1897

Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders

Article

Abstract

Ginger (rhizome of Zingiber officinale) has been widely used for centuries in gastrointestinal disorders, particularly dyspepsia, but its precise mode of action has yet to be elucidated. This study was undertaken to study the prokinetic action of ginger and its possible mechanism of action. Prokinetic activity of ginger extract (Zo.Cr) was confirmed in an in vivo test when it enhanced the intestinal travel of charcoal meal in mice. This propulsive effect of the extract, similar to that of carbachol, was blocked in atropine-pretreated mice, a standard cholinergic antagonist. Likewise, Zo.Cr showed an atropine-sensitive dose-dependent spasmogenic effect in vitro as well as in isolated rat and mouse stomach fundus tissues. In atropinized tissue, it showed spasmolytic activity as shown by the inhibition of 5-HT- and K+-induced contractions. A spasmolytic effect was also observed in other gut preparations either as noncompetitive inhibition of agonist dose–response curves, inhibition of high K+(80 mM)-induced contractions, or displacement of Ca2+ dose–response curves to the right, indicating a calcium antagonist effect. Phytochemical analysis revealed the presence of saponins, flavonoids, and alkaloids in the crude extract. These data indicate that Zo.Cr contains a cholinergic, spasmogenic component evident in stomach fundus preparations which provides a sound mechanistic insight for the prokinetic action of ginger. In addition, the presence of a spasmolytic constituent(s) of the calcium antagonist type may explain its use in hyperactive states of gut like colic and diarrhea.

Key Words

Zingiber officinale ginger prokinetic cholinergic calcium antagonist 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Muhammad Nabeel Ghayur
    • 1
  • Anwarul Hassan Gilani
    • 1
    • 2
  1. 1.Department of Biological and Biomedical SciencesThe Aga Khan University Medical CollegeKarachiPakistan
  2. 2.Department and SciencesThe Aga Khan University Medical CollegeKarachiPakistan

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