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Digestive Diseases and Sciences

, Volume 50, Issue 10, pp 1836–1838 | Cite as

Potentiation of Acetaminophen Hepatotoxicity by Phenytoin, Leading to Liver Transplantation

  • Scott M. Suchin
  • David C. Wolf
  • Young Lee
  • Gita Ramaswamy
  • Patricia A. Sheiner
  • Marcelo Facciuto
  • Michael R. Marvin
  • Leona Kim-schluger
  • Edward Lebovics
Case Report

Abstract

We report the case of a 22-year-old man who developed fulminant hepatic failure 3 days after an intentional acetaminophen overdose. The patient had a history of a seizure disorder for which he was taking phenytoin. The acetaminophen level at presentation was in the “nontoxic” range. Emergent liver transplantation was performed 4 days after the ingestion. This is the first reported case of successful liver transplantation for acetaminophen-induced fulminant hepatic failure in the setting of phenytoin therapy.

Key Words

acetaminophen phenytoin liver transplant fulminant hepatic failure 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Scott M. Suchin
    • 1
    • 2
  • David C. Wolf
    • 1
  • Young Lee
    • 1
  • Gita Ramaswamy
    • 1
  • Patricia A. Sheiner
    • 1
  • Marcelo Facciuto
    • 1
  • Michael R. Marvin
    • 1
  • Leona Kim-schluger
    • 1
  • Edward Lebovics
    • 1
  1. 1.Division of Gastroenterology and Hepatobiliary Diseases, Department of Surgery, and Division of Liver Transplant Surgery, Department of PathologyNew York Medical College, Westchester Medical CenterValhallaUSA
  2. 2.ScarsdaleUSA

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