Digestive Diseases and Sciences

, Volume 50, Issue 6, pp 1148–1155

Pegylated Interferon α -2a With or Without Ribavirin in HCV/HIV Coinfection: Partially Blinded, Randomized Multicenter Trial

  • Mandana Khalili
  • David Bernstein
  • Ellen Lentz
  • Christine Barylski
  • Margaret Hoffman-Terry
Article

Abstract

We evaluated the safety and efficacy of peginterferon α-2a (pegIFNα-2a), with or without ribavirin, in 154 HCV/HIV coinfected patients. All received pegIFNα-2a (180 μg/week) for 12 weeks, with those achieving an early virologic response (EVR) continued on monotherapy through week 48. Patients without an EVR were randomized at week 14 to also receive ribavirin (800 mg/day) or placebo through week 48. Patients with detectable HCV RNA at week 24 were discontinued. An EVR occurred in 59 of 154 patients on monotherapy, and a sustained virologic response (SVR) occurred in 19 of 55 of those achieving an EVR and continuing monotherapy through week 48. One week 12 nonresponder receiving pegIFNα-2a plus ribavirin, and none receiving pegIFNα -2a plus placebo, achieved a SVR. Discontinuations for adverse events occurred in 10 of 154 patients before, and 16 of 131 after, week 14. HIV RNA and CD4 counts did not change significantly during treatment. PegIFNα -2a was therefore at least as effective as standard interferon and ribavirin combination therapy and was well tolerated, without a negative impact on HIV parameters.

Key Words

pegIFNα-2a hepatitis C coinfection efficacy therapy 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Mandana Khalili
    • 1
    • 5
  • David Bernstein
    • 2
  • Ellen Lentz
    • 3
  • Christine Barylski
    • 3
  • Margaret Hoffman-Terry
    • 4
  1. 1.University of California, San FranciscoSan Francisco
  2. 2.Division of HepatologyNorth Shore University HospitalManhasset
  3. 3.Roche Laboratories Inc.Nutley
  4. 4.Lehigh Valley HospitalAllentownUSA
  5. 5.San Francisco General HospitalSan FranciscoUSA

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