Digestive Diseases and Sciences

, Volume 50, Issue 4, pp 609–616 | Cite as

Meta-analysis of Outcome of Cytomegalovirus Colitis in Immunocompetent Hosts

  • Polymnia Galiatsatos
  • Ian Shrier
  • Esther Lamoureux
  • Andrew Szilagyi
Review Article


There are only a few anecdotal reports of cytomegalovirus (CMV) colitis in immunocompetent hosts. The impact of the disease in this patient population remains poorly understood. The aim of this study was to perform a meta-analysis using individual patient data to determine outcomes of CMV colitis in immunocompetent patients and identify risk factors that might influence prognosis. A literature search was performed from 1980 to 2003 looking for immunocompetent patients with CMV colitis. Immunocompetence was defined as absence of congenital or acquired immune deficiency, transplant, or immunosuppressive medication. Patients were divided by age (< 55 versus ≥55) and grouped according to coexisting illnesses. Kaplan–Meier curves were plotted to assess survival. Variables included age, sex, site of acquisition of infection, extent of disease, coexisting illnesses, and treatment modality. A total of 44 patients were identified, with an average age of 61.1. Only 10 were free of any comorbidity. The mean follow-up was 13.4 months. Spontaneous remission occurred in 31.8%, mostly individuals < 55 years old. Fourteen deaths occurred, all of which were in patients ≥55. There was a higher mortality rate among male patients ≥55 (56.9%; P = 0.08), patients with immune-modulating diseases (75.2%; P = 0.10), and those having a colectomy (68.9%; P = 0.09). This analysis underlines the rarity of CMV colitis in patients with an intact immune system. Advanced age, male gender, presence of immune-modulating comorbidities, and need for surgical intervention are factors negatively influencing survival. Conversely, young healthy patients have a good prognosis with no intervention.


meta-analysis cytomegalovirus colitis 


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Polymnia Galiatsatos
    • 1
  • Ian Shrier
    • 2
  • Esther Lamoureux
    • 3
  • Andrew Szilagyi
    • 1
    • 4
  1. 1.Division of Gastroenterology, Department of MedicineMcGill UniversityMontrealCanada
  2. 2.Center for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical ResearchMcGill UniversityMontrealCanada
  3. 3.Department of Pathology, Sir Mortimer B. Davis Jewish General HospitalMcGill UniversityMontrealCanada
  4. 4.Division of GastroenterologyDepartment of MedicineMontrealCanada

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