Digestive Diseases and Sciences

, Volume 50, Issue 1, pp 15–17 | Cite as

Theoretical Flaws in the Gastric Emptying Breath Test: Why is it Dubious?

  • Masaki Sanaka
  • Takatsugu Yamamoto
  • Yasushi Kuyama
LETTER TO THE EDITOR

Keywords

Public Health Gastric Emptying Theoretical Flaw 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, Vantrappen G: Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104:1640–1647, 1993PubMedGoogle Scholar
  2. 2.
    Choi M-G, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Sreekumaran N: [$^{13}$C]Octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology 112:1155–1162, 1997PubMedGoogle Scholar
  3. 3.
    Delbende B, Perri F, Couturier O, Leodolter A, Mauger P, Bridgi B, Bizais Y, Varannes SB, Andriulli A, Galmiche JP: $^{13}$C-Octanoic acid breath test for gastric emptying measurement. Eur J Gastroenterol Hepatol 12:85–91, 2000CrossRefPubMedGoogle Scholar
  4. 4.
    Blick LJ, Harding M, French S, Wright A, Halliday D, Coward A: Measurement of gastric emptying in man using deuterated octanoic acid. Rapid Commun Mass Spectrom 16:127–133, 2002Google Scholar
  5. 5.
    Sanaka M, Yamamoto T, Ishii T, Kuyama Y: The Wagner-Nelson method can generate an accurate gastric emptying flow curve from 13CO2 data obtained by a 13C-labeled substrate breath test. Digestion 69:71–78, 2004PubMedGoogle Scholar
  6. 6.
    Saccomani MP, Bonadonna RC, Caveggion E, Defronzo RA, Cobelli C: Bicarbonate kinetics in humans: identification and validation of a three-compartmental model. Am J Physiol 269:E183–E192, 1995PubMedGoogle Scholar
  7. 7.
    Maughan RJ, Leiper JB: Methods for the assessment of gastric emptying in humans: an overview. Diab Med 20:S6–S10, 1996Google Scholar
  8. 8.
    Maes BD, Mys G, Geypens BJ, Evenepoel P, Ghoos YF, Rutgeerts PJ: Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results. Am J Physiol 275:G169–G175, 1998PubMedGoogle Scholar
  9. 9.
    Irving CS, Wong WW, Shulman RJ, Smith EO, Klein FD: [$^{13}$C]Bicarbonate kinetics in humans: intra-vs. interindividual variations. Am J Physiol 245:R190-R202, 1983PubMedGoogle Scholar
  10. 10.
    Hoerr RA, Yu Y-M, Wagner DA, Burke JF, Young VR: Recovery of 13C in breath from NaH13CO3 infused by gut and vein: effect of feeding. Am J Physiol 257:E426–E438, 1989.PubMedGoogle Scholar
  11. 11.
    Rowland M, Tozer TN. Clinical Pharmacokinetics—Concepts and Applications. 3rd Ed. Baltimore, Williams and Wilkins, 1995Google Scholar
  12. 12.
    Maes BD, Hiele MI, Geypens BJ, Rutgeerts PJ, Ghoos YF, G: Pharmacological modulation of gastric emptying rate of solids as measured by the carbon labelled octanoic acid breath test: influence of erythromycin and propantheline. Gut 35:333–337, 1994PubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Masaki Sanaka
    • 1
  • Takatsugu Yamamoto
    • 1
  • Yasushi Kuyama
    • 1
  1. 1.Department of Internal Medicine, School of MedicineTeikyo UniversityTokyoJapan

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