Digestive Diseases and Sciences

, Volume 49, Issue 11–12, pp 1899–1905 | Cite as

Advanced Colorectal Carcinomas Measuring 20 mm or Less Exhibit Markedly Higher Invasiveness Despite Their Size

  • Yasuhiro Kunii
  • Toshiki Kamano
  • Yuichi Tomiki
  • Shu Hirai
  • Shinji Kasamaki
  • Kazuhiro Sakamoto


To analyze the biology of small (20 mm or less) advanced colorectal carcinomas (SAC), 24 cases, 22 small early colorectal carcinomas (SEC) of similar size, and 52 advanced colorectal carcinomas (AC) were studied. The proliferative (Ki-67) labeling index for SAC was 65.9± 17.1%, significantly higher than those for SEC (30.9± 13.7%) or AC (43.0± 17.1%) (P &< 0.01). Matrix metalloproteinase (MMP)-9 and tissue inhibitors of metalloproteinase (TIMP)-2 expressions for SAC were 62.5 and 79.2%, respectively, significantly higher than those for SEC (4.5, 13.6%) or AC (21, 33%) (P &<0.01). Small advanced carcinomas have higher invasiveness than SEC or AC and may represent a different type of cancer.

colorectal cancer tumor proliferative activity tumor invasiveness 


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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Yasuhiro Kunii
    • 1
  • Toshiki Kamano
    • 1
  • Yuichi Tomiki
    • 1
  • Shu Hirai
    • 2
  • Shinji Kasamaki
    • 1
    • 2
  • Kazuhiro Sakamoto
    • 1
  1. 1.Department of Coloproctological SurgeryJuntendo University School of MedicineTokyoJapan
  2. 2.Department of PathologyJuntendo University School of MedicineTokyoJapan

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