Advertisement

Digestive Diseases and Sciences

, Volume 49, Issue 11–12, pp 1822–1829 | Cite as

Development and Validation of a Cross-Cultural Questionnaire to Evaluate Nonulcer Dyspepsia: The Porto Alegre Dyspeptic Symptoms Questionnaire (PADYQ)

  • Guilherme Becker SanderEmail author
  • Luiz Edmundo Mazzoleni
  • Carlos Fernando Magalhães Francesconi
  • André Castagna Wortmann
  • Eduardo André Ott
  • Alexandro Theil
  • Vicenzo Da Cruz Piccoli
  • Ângela Cristiane Da Silva
  • Leandro Oliveira
  • Simone Beheregaray
  • Simone Matioti
  • Gustavo Somm
  • José Roberto Goldim
Article

Abstract

Despite its high prevalence, nonulcer dyspepsia is still difficult to study, due to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease-specific questionnaire to evaluate patients with nonulcer dyspepsia. For that, the questionnaire was carefully written following widely accepted terminology, so as to facilitate translation and validation in other languages and cultures. The questionnaire was developed using Rome I terminology for symptoms, which were evaluated according to their intensity, duration, and frequency when applicable. Thirty-one patients with nonulcer dyspepsia, as well as 31 sex-and age-matched volunteers without digestive problems were used to assess the internal consistency, reproducibility, responsiveness, content validity, and discriminant validity of the questionnaire. Another 31 functional dyspeptic patients were enrolled for assessment of criterion validity. Cronbach’s α coefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86. The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at baseline (P=0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer dyspepsia. The median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P=0.001). An inverse correlation was observed between quality of life and dyspeptic symptoms (R = −0.28, P = 0.026). The proposed questionnaire has high degrees of both reproducibility and responsiveness. As this questionnaire was based on Rome I International Consensus terminology, it is expected that it will be easy to translate and validate.

dyspepsia questionnaires questionnaire design reproducibility of results 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Talley N, Stanghellini V, Heading RC, Koch KL, Nalagelada J, Tytgat G. Functional gastroduodenal disorders. In The Functional Gastrointestinal Disorders, 2nd ed. Drossman DA, Corazziari E, Talley N, Thompson WG, Whitehead WE (eds). Lawrence, Degnon Associates, 2000 pp. 299–350Google Scholar
  2. 2.
    Holtmann G, Gschossmann J, Neufang-Huber J, Gerken G, Talley NJ: Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls. Gut 47(3):332–336, 2000CrossRefGoogle Scholar
  3. 3.
    Mearin F, Cucala M, Azpiroz F, Malagelada JR: The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 101(4):999–1006, 1991CrossRefGoogle Scholar
  4. 4.
    Fennerty MB: Is nonulcer dyspepsia related to Helicobacter pylori infection? Semin Gastrointest Dis 12(3):180–185, 2001PubMedGoogle Scholar
  5. 5.
    Talley NJ, Colin-Jones D, Koch K, Koch M, Nyren O, Stanghellini V: Functional dyspesia: A classification with guidelines for diagnosis and management. Gastroenterol Int 4:145–160, 1991Google Scholar
  6. 6.
    Kirschner B, Guyatt G: A methodological framework for assessing health indices. J Chronic Dis 38(1):27–36, 1985CrossRefGoogle Scholar
  7. 7.
    Sperber AD: Translation and validation of study instruments for cross-cultural research. Gastroenterology 126:s12.4–128, 2004CrossRefGoogle Scholar
  8. 8.
    Streiner DL, Norman GR: Health Measurement Scales, 2nd ed. Oxford, Oxford Medical, 1995Google Scholar
  9. 9.
    Cronbach L: Coefficient alpha and the internal structure of tests. Psychometrika 16(3):297–334, 1951CrossRefGoogle Scholar
  10. 10.
    Streiner DL, Norman GR: Selecting the items. In Health Measurement Scales, 2nd ed. Oxford, Oxford Medical, Publications, 1995.Google Scholar
  11. 11.
    Fachel J, Carney S: Avlição psicomátrica: A qualidade das medidas e o entendimento dos dados. In: Cunha J (ed). Psicodiagnstico V. Porto Alegre, Artmed Editora, 2000Google Scholar
  12. 12.
    Shaw M, Talley NJ, Adlis S, Beebe T, Tomshine P, Healey M. Development of a digestive health status instrument: Tests of scaling assumptions, structur and reliability in a primary care population. Aliment Pharmacol Ther 12(11):1067–1078, 1998CrossRefGoogle Scholar
  13. 13.
    O’Leary MP, Barry MJ, Fowler FJ Jr: Hard measures of subjective outcomes: Validating symptom indexes in urology. J Urol 148(5):1546–1548, 1992CrossRefGoogle Scholar
  14. 14.
    Talley NJ, Verlinden M, Jones M: Quality of life in functional dyspepsia: Responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Aliment Pharmacol Ther 15(2):207–216, 2001CrossRefGoogle Scholar
  15. 15.
    Streiner DL, Norman GR: Health Measurement Scales, 2nd ed. Oxford, Oxford Medical, 1995Google Scholar
  16. 16.
    Liang MH: Evaluating measurement reponsiveness. J Rheumatol 22(6):1191–1192, 1995PubMedGoogle Scholar
  17. 17.
    Fleck M, Louzada S, Xavier M, Chachamovich E, Vieira RR, Santos L, Pinzon V: Aplicação da versão em português do instrumento de avaliação de qualidade de vida da Organização Mundial da Saúde (WHOQOL-100). Rev Saude Publica 33(2):198–205, 1999CrossRefGoogle Scholar
  18. 18.
    Chassany O, Marquis P, Scherrer B, Read NW, Finger T, Bergmann JF, Fraitag B, Geneve J, Caulin C: Validation of a specific quality of life questionnaire for functional digestive disorders. Gut 44(4):527–533, 1999CrossRefGoogle Scholar
  19. 19.
    Streiner DL, Norman GR: Validity: In Health Measurement Scales, 2nd ed. Oxford, Oxford Medical, 1995Google Scholar
  20. 20.
    Fleck MP, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L, Pinzon V: [Application of the Portuguese version of the abbreviated instrument of quality life WHOQOL-bref]. Rev Saude Publica 34(2):178–183, 2000CrossRefGoogle Scholar
  21. 21.
    Almeida TL: Anlise fatorial. http://lula.dmat.furg.b/∼taba/posanafat.htm. Accessed 6 Aug 2003Google Scholar
  22. 22.
    van Zanten SJ, Talley NJ, Blum AL, Bolling-Sternevald E, Sundin M, Junghard O: Combined analysis of the ORCHID and OCAY studies: Does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms? Gut 50 (Suppl 4):iv26–iv30, 2002Google Scholar
  23. 23.
    van Zanten SJ: Assessment of outcome in dyspepsia: Has progress been made? Gut 50 (Suppl 4):iv23–iv25, 2002Google Scholar
  24. 24.
    Streiner DL: Sample size formulae for parameter estimation. Percept Mot Skills 78:275–284, 1994CrossRefGoogle Scholar
  25. 25.
    van Zanten SJ, Tytgat KM, Pollak PT, Goldie J, Goodacre RL, Riddell RH, Hunt RH: Can severity of symptoms be used as an outcome measure in trials of nonulcer dyspepsia and Helicobacter pylori associated gastritis? J Clin Epidemiol 46(3):273–279, 1993CrossRefGoogle Scholar
  26. 26.
    Buckley MJ, Scanlon C, McGurgan P, O’Morain CA: A validated dyspepsia symptom score. Ital J Gastroenterol Hepatol 29(6):495–500, 1997PubMedGoogle Scholar
  27. 27.
    Drossman DA: Chronic abdominal pain (with emphasis on functional abdominal pain syndrome). In Feldman, Sleisenger & Fordtran’s Gastrointestinal and liver disease, 7th ed. Feldman M, Scharschimidt BF, Sleisenger MH (eds). Philadelphia, W. B. Saunders, 2002 Google Scholar
  28. 28.
    El Omar EM, Banerjee S, Wirz A, McColl K: The Glasgow Dyspepsia Severity Score—A tool for the global measurement of dyspepsia. Eur J Gastroenterol Hepatol 8(10):967–971, 1996CrossRefGoogle Scholar
  29. 29.
    Junghard O, Lauritsen K, Talley NJ, Wiklund IK: Validation of seven graded diary cards for severity of dyspeptic symptoms in patients with non ulcer dyspepsia. Eur J Surg Suppl 583:106–111, 1998Google Scholar
  30. 30.
    Svedlund J, Sjdin I, Dotevall G: GSRS—A clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease. Dig Dis Sci 33:129–134, 1988CrossRefGoogle Scholar
  31. 31.
    Jaakkimainen RL, Boyle E, Tudiver F: Is Helicobacter pylori associated with nonulcer dyspepsia and will eradication improve symptoms? A meta-analysis. BMJ 319:1040–1044, 1999PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Guilherme Becker Sander
    • 1
    Email author
  • Luiz Edmundo Mazzoleni
    • 1
  • Carlos Fernando Magalhães Francesconi
    • 1
  • André Castagna Wortmann
    • 1
  • Eduardo André Ott
    • 1
  • Alexandro Theil
    • 1
  • Vicenzo Da Cruz Piccoli
    • 1
  • Ângela Cristiane Da Silva
    • 1
  • Leandro Oliveira
    • 1
  • Simone Beheregaray
    • 1
  • Simone Matioti
    • 1
  • Gustavo Somm
    • 1
  • José Roberto Goldim
    • 1
  1. 1. Graduate Program in GastroenterologyUniversidade Federal do Rio Grande do SulPort AlegreBrazil

Personalised recommendations