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Cytotechnology

, Volume 71, Issue 5, pp 1003–1017 | Cite as

Sambucus nigra L. ameliorates UVB-induced photoaging and inflammatory response in human skin keratinocytes

  • Pei Lin
  • Eunson Hwang
  • Hien T. T. Ngo
  • Seul A. Seo
  • Tae-Hoo YiEmail author
Original Article
  • 79 Downloads

Abstract

Sambucus nigra L. (Elderberry) is widely used as a dietary supplement in functional food and possesses many pharmacological activities to prevent ailments, such as the colds and fever, diabetes and cancer. However, research on its skin anti-aging effect is still limited. Here, we evaluated the recovery effects of elderberry extract (EB) in UVB-irradiated human skin keratinocytes (HaCaTs) and investigated whether EB represents a potential therapeutic agent against skin photoaging and inflammation. In this study, EB showed good efficiency on scavenging free radicals and dose-dependently reduced reactive oxygen species (ROS) generation. EB notably decreased UVB-induced matrix metalloproteinase-1 (MMP-1) expression and inflammatory cytokine secretion through the inhibition of mitogen-activated protein kinases/activator protein 1 (MAPK/AP-1) and nuclear factor-κB (NF-κB) signaling pathways, blocking extracellular matrix (ECM) degradation and inflammation in UVB-irradiated HaCaTs. In addition, EB improved nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling to increase oxidative defense capacity, and enhanced transforming growth factor beta (TGF-β) signaling activation to promote procollagen type I synthesis, relieving UVB-induced skin cell damage. These results indicated that EB has the potential to ameliorate UVB-induced skin photoaging and inflammation.

Keywords

Elderberry UVB irradiation HaCaTs Photoaging ROS MMP-1 

Notes

Acknowledgements

This work was supported by the Snow White Factory Inc., Republic of Korea.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.College of Life ScienceKyung Hee UniversityYongin-siRepublic of Korea

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