, Volume 70, Issue 3, pp 993–999 | Cite as

Antidiabetic effects of novel cell culture established from grapevine, Vitis vinifera cv. Koshu

  • Keiko Fujita
  • Yoshinao Aoki
  • Shunji SuzukiEmail author
Short Communication


Vitis vinifera cv. Koshu is an indigenous cultivar in Japan and has several characteristics that distinguish it from European V. vinifera. In Japan, Koshu is the most popular cultivar for wine making. We report herein a cell culture established from Koshu for use as a system for the production of resveratrol and its derivatives. Grape cell culture YU-1 was developed from the apex tissues of Koshu. YU-1 growth was favorably compared with BY-2 growth, a standard cell line in plant cell biology. Stilbene production and stilbene synthesis gene expression in YU-1 were upregulated by UV-C irradiation. YU-1 irradiated with UV-C decreased hemolymph sugar levels in model animals. Taken together, this study suggests that YU-1 may be used as a source of valuable medicinal components in plant cell bioreactor systems.


Antidiabetic Hypoglycemic effect Koshu Resveratrol Vitis vinifera 



We thank Dr. Hironori Kobayashi and Dr. Ryoji Takata (Kirin Company, Ltd.) for valuable discussion.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Faculty of Life and Environmental SciencesPrefectural University of HiroshimaHiroshimaJapan
  2. 2.Laboratory of Fruit Genetic Engineering, The Institute of Enology and ViticultureUniversity of YamanashiKofuJapan

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