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Cytotechnology

, Volume 62, Issue 4, pp 367–376 | Cite as

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

  • Young-Sil Lee
  • Byung-Yoon Cha
  • Kohji Yamaguchi
  • Sun-Sil Choi
  • Takayuki Yonezawa
  • Toshiaki Teruya
  • Kazuo Nagai
  • Je-Tae Woo
JAACT Special Issue

Abstract

The present study examined the anti-obesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/w) KGE diet (HFD + 0.8KGE and HFD + 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD + 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD + 0.8KGE and HFD + 1.6KGE groups, while leptin levels were significantly decreased in only the HFD + 1.6KGE group, compared with the HFD group. The HFD + 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorγ2 (PPARγ2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

Keywords

Korean white ginseng High-fat diet-induced obese mice Lipogenesis-related genes Intestinal fat absorption 

Notes

Acknowledgment

This study was performed at a laboratory which is supported by an endowment from ERINA CO., INC.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Young-Sil Lee
    • 1
  • Byung-Yoon Cha
    • 1
  • Kohji Yamaguchi
    • 1
  • Sun-Sil Choi
    • 1
  • Takayuki Yonezawa
    • 1
  • Toshiaki Teruya
    • 1
  • Kazuo Nagai
    • 1
    • 2
  • Je-Tae Woo
    • 1
    • 2
  1. 1.Research Institute for Biological FunctionsChubu UniversityKasugaiJapan
  2. 2.Department of Biological ChemistryChubu UniversityKasugaiJapan

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