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Feasibility and Impact of a Guided Symptom Exposure Augmented Cognitive Behavior Therapy Protocol to Prevent Symptoms of Pharmacologically Induced Depression: A Pilot Study

  • Lata K. McGinnEmail author
  • Anna Van Meter
  • Ian Kronish
  • Jessica Gashin
  • Karen Burns
  • Natalie Kil
  • Thomas G. McGinn
Original Article

Abstract

Depression is the leading cause of disability and a major cause of morbidity worldwide, with societal costs now upwards of 1 trillion dollars across the globe. Hence, extending current efforts to augment prevention outcomes is consistent with global public health interests. Although many prevention programs have been developed and have demonstrated efficacy, studies have yet to demonstrate that CBT is effective in preventing symptoms in populations at risk for developing depression induced by pharmacological substances. Using a randomized, controlled design, this pilot study reports on the feasibility and preliminary effects of a novel, guided symptom exposure augmented cognitive behavioral prevention intervention (GSE-CBT) in a sample diagnosed with Hepatitis C at risk for developing medication induced depression. Results demonstrated that the guided symptom exposure augmented CBT (GSE-CBT) was feasible in this population and was delivered with high integrity. Although not statistically different, we observed a pattern of lower depression levels in the GSE-CBT group versus those in the control group throughout. This pilot study demonstrates that a psychosocial prevention intervention is feasible for use in patients at risk for developing pharmacologically induced depression and that a guided symptom exposure augmented CBT protocol has the potential to prevent symptoms of depression that develop as a side effect to taking these medications. Results are preliminary and future studies should use larger samples and test the intervention in other populations.

Keywords

Depression Prevention Adulthood CBT Exposure Interoceptive exposure Mood induction Hepatitis Interferon 

Notes

Funding

This study was funded by the National Institute of Health. R23- DA021531-01 NIDA (NIH).

Compliance with Ethical Standards

Conflict of interest

Lata K. McGinn, Anna Van Meter, Ian Kronish, Jessica Gashin, Karen Burns, Natalie Kil and Thomas G. McGinn declare that they have no competing interests to report.

Informed consent and Animal Rights

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. No animal studies were carried out by the authors for this paper.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Ferkauf Graduate School of PsychologyYeshiva UniversityBronxUSA
  2. 2.Mount Sinai Medical CenterNew YorkUSA
  3. 3.The Feinstein Institute for Medical Research, The Zucker Hillside Hospital, Psychiatry ResearchGlen OaksUSA
  4. 4.Division of General MedicineColumbia Presbyterian HospitalNew YorkUSA
  5. 5.Department of MedicineHofstra Northwell School of MedicineManhassetUSA

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