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Biological Studies with Phytochemical Analysis Of Cornus mas Unripe Fruits

  • S. Moussouni
  • C. V. Karakousi
  • P. Tsatalas
  • D. Lazari
  • E. KokkalouEmail author
Article
  • 8 Downloads
Cornus fruits are widely known for possessing anticancer, anti-inflammatory, antioxidant, and hypoglycemic effects [ 1, 2, 3, 4]. Biological and phytochemical studies of C. mas (L.) unripe fruits are reported for the first time in this study. The aim of the study was the detection and isolation of biosynthetic precursors of compounds found in the mature fruits. The LC-DAD-MS (ESI+) analysis revealed the presence of 3-ferulic-3′-ellagic-difuranoside, scandoside methyl ester, and swertiamarin in the diethyl ether fraction, and cornuside II in the ethyl acetate fraction. All compounds were found for the first time in C. mas L. Tentative structures for the main metabolites (Table 1) were proposed based on UV-vis spectra and fragmentation patterns [ 5]. Simultaneously our investigation of the Et 2O and EtOAc fractions resulted in the isolation of trans-ferulic acid ( 1) [ 6], gallic acid ( 2) [ 7], methyl gallate ( 3) [ 7], protocatechuic acid ( 4) [ 6], methyl caffeate ( 5) [ 8], trans- p-coumaric acid...

Notes

Acknowledgment

We would like to thank Doulias Konstantinos for the plant collection, Dr. Theano Samara for the plant identification, and Dr. M. Chatzopoulou for her contribution in the measurements with the aldose reductase enzymes.

References

  1. 1.
    B. Yousefi, M. Abasi, M. M. Abbasi, and R. Jahanban-Esfahlan, Asian Pac. J. Cancer Prev., 16, 5727 (2015).Google Scholar
  2. 2.
    N. P. Seeram, R. Schutzki, A. Chandra, and M. G. Nair, J. Agric. Food Chem., 50, 2519 (2002).CrossRefGoogle Scholar
  3. 3.
    S. Tulipani, B. Mezzetti, F. Capocasa, S. Bompadre, J. Beekwilder, C. H. De Vos, E. Capanoglu, A. Bovy, and M. Battino, J. Agric. Food Chem., 56, 696 (2008).CrossRefGoogle Scholar
  4. 4.
    R. Soltani, A. Gorji, S. Asgary, N. Sarrafzadegan, and M. Siavash, Evid. Based Complement Altern. Med., ID 740954 (2015).Google Scholar
  5. 5.
    P. Kefalas and D. P. Makris, Res. Signpost, 37, 661 (2006).Google Scholar
  6. 6.
    C. R. Liao, Y. H. Kuo, Y. L. Ho, C. Y. Wang, C. S. Yang, C. W. Lin, and Y. S. Chang, Molecules, 19, 9515 (2014).CrossRefGoogle Scholar
  7. 7.
    K. J. Wang, C. R. Yang, and Y. J. Zhang, Food Chem., 101, 365 (2007).Google Scholar
  8. 8.
    H. T. Aung, T. Furukawa, T. Nikai, M. Niwa, and Y. Takaya, Bioorg. Med. Chem., 19, 2392 (2011).Google Scholar
  9. 9.
    X. Tian, S. Guo, K. He, M. Roller, M. Yang, Q. Liu, L. Zhang, C. Tang Ho, and N. Bai, Nat. Prod. Res., 32, 354 (2018).Google Scholar
  10. 10.
    Z. He, W. Lian, J. Liu, R. Zheng, H. Xu, G. Du, and A. Liu, Phytochem. Lett., 19, 160 (2017).Google Scholar
  11. 11.
    M. Miyazawa, J. Anzai, J. Fujioka, and Y. Isikawa, Nat. Prod. Res., 17, 337 (2003).Google Scholar
  12. 12.
    J. H. Moon, T. Tsushida, K. Nakahara, and J. Terao, Free Radic. Biol. Med., 30, 1274 (2001).Google Scholar
  13. 13.
    D. Duan, Z. Li, H. Luo, W. Zhang, L. Chen, and X. Xu, Bioorg. Med. Chem. Lett., 14, 6041 (2004).Google Scholar
  14. 14.
    T. Tanaka, G. I. Nonaka, and I. Nishioka, Phytochemistry, 24, 2075 (1985).CrossRefGoogle Scholar
  15. 15.
    A. Arnous, D. P. Makris, and P. Kefalas, J. Food Compos. Anal., 15, 655 (2002).Google Scholar
  16. 16.
    I. Parejo, C. Codina, C. Petrakis, and P. Kefalas, J. Pharmacol. Toxicol. Methods, 44, 507 (2000).Google Scholar
  17. 17.
    M. Chatzopoulou, E. Mamadou, M. Juskova, C. Koukoulitsa, I. Nicolaou, M. Stefek, and V. J. Demopoulos, Bioorg. Med. Chem., 19, 1426 (2011).Google Scholar
  18. 18.
    J. A. de la Fuente and S. Manzanaro, Nat. Prod. Rep., 20, 243 (2003).CrossRefGoogle Scholar
  19. 19.
    P. Alexiou and V. J. Demopoulos, J. Med. Chem., 53, 7756 (2010).Google Scholar
  20. 20.
    A. M. Katsori, M. Chatzopoulou, K. Dimas, C. Kontogiorgis, T. Patsilinakos Trangas, and D. Hadjipavlou-Litina, Eur. J. Med. Chem., 46, 2722 (2011).Google Scholar
  21. 21.
    T. M. Ngoc, T. M. Hung, P. T. Thuong, J. C. Kim, J. S. Choi, K. Bae, M. Hattori, C. S. Choi, J. S. Lee, and B. S. Min, Biosci. Biotechnol. Biochem., 72, 2158 (2008).Google Scholar
  22. 22.
    T. J. Ha, K. Shimizu, T. Ogura, and I. Kubo, Chem. Biodiv., 7, 1893 (2010).Google Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • S. Moussouni
    • 1
  • C. V. Karakousi
    • 1
  • P. Tsatalas
    • 1
  • D. Lazari
    • 1
  • E. Kokkalou
    • 1
    Email author
  1. 1.Laboratory of Pharmacognosy and Natural Products, School of PharmacyAristotle University of ThessalonikiThessalonikiGreece

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