Biological Studies with Phytochemical Analysis Of Cornus mas Unripe Fruits

  • S. Moussouni
  • C. V. Karakousi
  • P. Tsatalas
  • D. Lazari
  • E. KokkalouEmail author
Cornus fruits are widely known for possessing anticancer, anti-inflammatory, antioxidant, and hypoglycemic effects [ 1, 2, 3, 4]. Biological and phytochemical studies of C. mas (L.) unripe fruits are reported for the first time in this study. The aim of the study was the detection and isolation of biosynthetic precursors of compounds found in the mature fruits. The LC-DAD-MS (ESI+) analysis revealed the presence of 3-ferulic-3′-ellagic-difuranoside, scandoside methyl ester, and swertiamarin in the diethyl ether fraction, and cornuside II in the ethyl acetate fraction. All compounds were found for the first time in C. mas L. Tentative structures for the main metabolites (Table 1) were proposed based on UV-vis spectra and fragmentation patterns [ 5]. Simultaneously our investigation of the Et 2O and EtOAc fractions resulted in the isolation of trans-ferulic acid ( 1) [ 6], gallic acid ( 2) [ 7], methyl gallate ( 3) [ 7], protocatechuic acid ( 4) [ 6], methyl caffeate ( 5) [ 8], trans- p-coumaric acid...



We would like to thank Doulias Konstantinos for the plant collection, Dr. Theano Samara for the plant identification, and Dr. M. Chatzopoulou for her contribution in the measurements with the aldose reductase enzymes.


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Authors and Affiliations

  • S. Moussouni
    • 1
  • C. V. Karakousi
    • 1
  • P. Tsatalas
    • 1
  • D. Lazari
    • 1
  • E. Kokkalou
    • 1
    Email author
  1. 1.Laboratory of Pharmacognosy and Natural Products, School of PharmacyAristotle University of ThessalonikiThessalonikiGreece

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