Advertisement

Chemistry of Natural Compounds

, Volume 55, Issue 6, pp 1179–1181 | Cite as

Anti-Influenza Activity of Several Caryophyllane Hiosesquiterpenoids

  • Yu. V. GyrdymovaEmail author
  • E. O. Sinegubova
  • A. S. Muryleva
  • V. V. Zarubaev
  • S. A. Rubtsova
Article
  • 18 Downloads

Seasonal influenza is an acute respiratory infection caused by influenza viruses spreading over the whole world. Influenza virus A is responsible for most infections, including those with lethal outcomes. Treatments of patient infected with this type of virus are complicated by possible resistance to all existing drugs. This was most evident in 2007−2009 when an oseltamivir-resistant phenotype appeared among practically all virus subtype H1N1 isolates [1, 2, 3]. Natural compounds can act as promising antiviral agents. Several monoterpene derivatives are known to be active against influenza virus type A [4, 5]. The only sesquiterpene with such activity is isocaryophyllene acetamide [6]. The anti-influenza activity of S-containing sesquiterpenoids has not been reported. Therefore, studies of the antiviral properties of sesquiterpenes containing S-groups are crucial and of indubitable practical interest.

The antioxidant and membrane-protective properties of thiosesquiterpenoids...

Notes

Acknowledgment

The work was financially supported by the RFBR (Project No. 18-33-00846 mol_a).

References

  1. 1.
    J. LeGoff, D. Rousset, G. Abou-Jaoud, A. Scemla, P. Ribaud, S. Mercier-Delarue, V. Caro, V. Enouf, F. Simon, J.-M. Molina, and S. van der Werf, PLoS One, 7 (8), e37095 (2012).CrossRefGoogle Scholar
  2. 2.
    A. Pizzorno, Y. Abed, X. Bouhy, E. Beaulieu, C. Mallett, R. Russell, and G. Boivin, Antimicrob. Agents Chemother., 56 (3), 1208 (2012).CrossRefGoogle Scholar
  3. 3.
    R. Trebbien, S. S. Pedersen, K. Vorborg, K. T. Franck, and T. K. Fischer, Euro Surveill., 22 (3), 30445 (2017).CrossRefGoogle Scholar
  4. 4.
    O. S. Patrusheva, V. V. Zarubaev, A. A. Shtro, Y. R. Orshanskaya, S. A. Boldyrev, I. V. Ilyina, S. Y. Kurbakova, D. V. Korchagina, K. P. Volcho, and N. F. Salakhutdinov, Bioorg. Med. Chem., 24 (21), 5158 (2016).CrossRefGoogle Scholar
  5. 5.
    A. S. Sokolova, O. I. Yarovaya, A. V. Shernyukov, Y. V. Gatilov, Y. V. Razumova, V. V. Zarubaev, T. S. Tretiak, A. G. Pokrovsky, O. I. Kiselev, and N. F. Salakhutdinov, Eur. J. Med. Chem., 105, 263 (2015).CrossRefGoogle Scholar
  6. 6.
    O. I. Yarovaya, A. A. Shtro, Ya. R. Orshanskaya, V. V. Zarubaev, V. A. Khazanov, and N. F. Salakhutdinov, RU Pat. 2,616,255 C1, Apr. 13, 2017; Byull., No. 11, 1 (2017).Google Scholar
  7. 7.
    Yu. V. Gyrdymova, D. V. Sudarikov, O. G. Shevchenko, S. A. Rubtsova, P. A. Slepukhin, and A. V. Kutchin, Chem. Biodiversity, 14, e1700296 (2017).CrossRefGoogle Scholar
  8. 8.
    Yu. V. Gyrdymova, D. V. Sudarikov, S. A. Rubtsova, P. A. Slepukhin, and A. V. Kutchin, Chem. Nat. Compd., 53, 463 (2017).CrossRefGoogle Scholar
  9. 9.
    Yu. V. Gyrdymova, D. V. Sudarikov, S. A. Rubtsova, and A. V. Kutchin, Russ. J. Org. Chem., 53 (6), 853 (2017).CrossRefGoogle Scholar
  10. 10.
    K. S. Rodygin, Yu. V. Gyrdymova, and V. V. Zarubaev, Mendeleev Commun., 27 (5), 476 (2017).CrossRefGoogle Scholar
  11. 11.
    T. Mossman, J. Immunol. Methods, 65, 55 (1983).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yu. V. Gyrdymova
    • 1
    Email author
  • E. O. Sinegubova
    • 2
  • A. S. Muryleva
    • 2
  • V. V. Zarubaev
    • 2
  • S. A. Rubtsova
    • 1
  1. 1.Institute of Chemistry, FRC, Komi SC, Ural Branch, Russian Academy of SciencesSyktyvkarRussia
  2. 2.Pasteur Research Institute of Epidemiology and MicrobiologySt. PetersburgRussia

Personalised recommendations