Study of the Low Polar Constituents from the Endophytic Fungus Annulohypoxylon ilanense
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Microorganisms are potentially exploitable for biotechnological processes, in particular for the development of new antibiotics, probiotics, enzymes, and polymers with pharmaceutical and industrial applications. Endophytes are regarded as a type of special biotope microorganism as they reside in the tissues of living plants or animals without causing any apparent symptoms [1, 2, 3]. Most reports on endophytes have demonstrated their diversity and potential as a source for bioactive compounds [4, 5, 6]. In previous research carried out by our group on the secondary metabolites from endophytes, a series of new compounds was isolated with biological activities.
As part of our continuous chemical investigation of plant endophytes, a hexane-soluble extract of the endophytic fungus Annulohypoxylon ilanense was studied, leading to the isolation of five nonpolar known compounds, methyl (13S)-(9Z,11E)-13-hydroxyoctadeca-9,11-dienoate (1) , (9Z,12Z,15Z)-2,3-dihydroxypropyl...
The authors thank Senior Technician Mrs. Chyi-Jia Wang of Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University (KMU) for measuring the 2D NMR data. This work was kindly supported by the Food Industry Research and Development Institute (FIRDI) and Ministry of Science and Technology, R.O.C. (MOST-108-2320-B-080-002).We thank Renee Mosi, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.