Chemistry of Natural Compounds

, Volume 55, Issue 6, pp 1131–1132 | Cite as

Study of the Low Polar Constituents from the Endophytic Fungus Annulohypoxylon ilanense

  • Yung-Shun Su
  • Ming Jen ChengEmail author
  • Ming-Der Wu
  • Sung Yuan Hsieh
  • Chee-Yin Chai
  • Aij-Li Kwan

Microorganisms are potentially exploitable for biotechnological processes, in particular for the development of new antibiotics, probiotics, enzymes, and polymers with pharmaceutical and industrial applications. Endophytes are regarded as a type of special biotope microorganism as they reside in the tissues of living plants or animals without causing any apparent symptoms [1, 2, 3]. Most reports on endophytes have demonstrated their diversity and potential as a source for bioactive compounds [4, 5, 6]. In previous research carried out by our group on the secondary metabolites from endophytes, a series of new compounds was isolated with biological activities.

As part of our continuous chemical investigation of plant endophytes, a hexane-soluble extract of the endophytic fungus Annulohypoxylon ilanense was studied, leading to the isolation of five nonpolar known compounds, methyl (13S)-(9Z,11E)-13-hydroxyoctadeca-9,11-dienoate (1) [7], (9Z,12Z,15Z)-2,3-dihydroxypropyl...



The authors thank Senior Technician Mrs. Chyi-Jia Wang of Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University (KMU) for measuring the 2D NMR data. This work was kindly supported by the Food Industry Research and Development Institute (FIRDI) and Ministry of Science and Technology, R.O.C. (MOST-108-2320-B-080-002).We thank Renee Mosi, PhD, from Edanz Group ( for editing a draft of this manuscript.


  1. 1.
    B. Schulz and C. Boyle, Mycol. Res., 109, 661 (2005).CrossRefGoogle Scholar
  2. 2.
    R. X. Tan and W. X. Zou, Nat. Prod. Rep., 18, 448 (2001).CrossRefGoogle Scholar
  3. 3.
    A. A. L. Gunatilaka, J. Nat. Prod., 69, 509 (2006).CrossRefGoogle Scholar
  4. 4.
    J. W. Blunt, B. R. Copp, M. H. G. Munro, P. T. Northcote, and M. R. Prinsep, Nat. Prod. Rep., 28, 196 (2011).CrossRefGoogle Scholar
  5. 5.
    R. J. Capon, M. Stewart, R. Ratnayake, E. Lacey, and J. H. Gill, J. Nat. Prod., 70, 1746 (2007).CrossRefGoogle Scholar
  6. 6.
    H. B. Park, H. C. Kwon, C. H. Lee, and H. O. Yang, J. Nat. Prod., 72, 248 (2009).CrossRefGoogle Scholar
  7. 7.
    J. S. Yadav, P. K. Deshpande, and G. V. M. Sharma, Tetrahedron, 48, 4465 (1992).CrossRefGoogle Scholar
  8. 8.
    B. H. Fraser P. Perlmutter, and C. Wijesundera, J. Am. Oil Chem. Soc., 84, 11 (2007).CrossRefGoogle Scholar
  9. 9.
    K. R. Markham, K. A. Mitchell, A. L. Wilkins, J. A. Daldy, and Y. Lu, Phytochemistry, 42, 205 (1996).CrossRefGoogle Scholar
  10. 10.
    M. Rejzek, M. Vacek, and Z. Wimmer, Helv. Chim. Acta, 83, 2756 (2000).CrossRefGoogle Scholar
  11. 11.
    Y. M. Chiang and Y. H. Kuo, Tetrahedron Lett., 44, 5125 (2003).CrossRefGoogle Scholar
  12. 12.
    M. J. Cheng, M. D. Wu, J. J. Chen, S. Y. Hsieh, G. F. Yuan, I. H. Chen, and C. W. Chang, Chem. Nat. Compd., 49, 523 (2013).CrossRefGoogle Scholar
  13. 13.
    M. D. Wu, M. J. Cheng, I. H. Chen, Y. S. Su, S. Y. Hsieh, H. S. Chang, C. W. Chang, and G. F. Yuan, Chem. Biodiv., 10, 493 (2013).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yung-Shun Su
    • 1
  • Ming Jen Cheng
    • 2
    Email author
  • Ming-Der Wu
    • 2
  • Sung Yuan Hsieh
    • 2
  • Chee-Yin Chai
    • 1
    • 3
  • Aij-Li Kwan
    • 1
    • 4
  1. 1.Graduate Institute of Medicine, College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan
  2. 2.Bioresource Collection and Research Center (BCRC)Food Industry Research and Development Institute (FIRDI)HsinchuTaiwan
  3. 3.Department of PathologyKaohsiung Medical University Chung-Ho Memorial HospitalKaohsiungTaiwan
  4. 4.Department of NeurosurgeryKaohsiung Medical University Chung-Ho Memorial HospitalKaohsiungTaiwan

Personalised recommendations