A New Coumarin from Zanthoxylum nitidum
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One new coumarin compound, isopranferin (1), along with six known compounds 2–7, were isolated from Zanthoxylum nitidum. Their structures were determined on the basis of spectral data including 1D and 2D NMR and HR-EI-MS. Compounds 2–4, 6, and 7 were isolated from this plant for the first time. The in vitro cytotoxicity of compounds 1–7 to RAW264.7 cells, THP-1 cells, and Caco-2 cells was firstly tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods.
KeywordsZanthoxylum nitidum coumarin isopranferin cytotoxicity
We gratefully acknowledge the financial support of this work by National Key Project of Science and Technology of China “Important New Drugs Innovation,” 2017ZX09301045, Strategic Priority Research Program of the Chinese Academy of Sciences, XDA12050302, XDA12040321, and Foundation of XTBG, 2017XTBG-F02. This work was also supported by the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences, ZSTH-022, and Foundation of Yunnan Natural Science, 2014FA043.
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