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Chemistry of Natural Compounds

, Volume 55, Issue 6, pp 1010–1013 | Cite as

A New Coumarin from Zanthoxylum nitidum

  • Lan Zhou
  • Wencui Chen
  • Wenqian He
  • Yumei Zhang
  • Pianchou Gongpan
  • Qingfei FanEmail author
  • Qishi SongEmail author
Article
  • 20 Downloads

One new coumarin compound, isopranferin (1), along with six known compounds 2–7, were isolated from Zanthoxylum nitidum. Their structures were determined on the basis of spectral data including 1D and 2D NMR and HR-EI-MS. Compounds 2–4, 6, and 7 were isolated from this plant for the first time. The in vitro cytotoxicity of compounds 1–7 to RAW264.7 cells, THP-1 cells, and Caco-2 cells was firstly tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods.

Keywords

Zanthoxylum nitidum coumarin isopranferin cytotoxicity 

Notes

Acknowledgment

We gratefully acknowledge the financial support of this work by National Key Project of Science and Technology of China “Important New Drugs Innovation,” 2017ZX09301045, Strategic Priority Research Program of the Chinese Academy of Sciences, XDA12050302, XDA12040321, and Foundation of XTBG, 2017XTBG-F02. This work was also supported by the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences, ZSTH-022, and Foundation of Yunnan Natural Science, 2014FA043.

References

  1. 1.
    C. Yang, M. Cheng, S. Lee, C. Yang, H. Chang, and I. Chen, Chem. Biodiv., 6, 846 (2009).CrossRefGoogle Scholar
  2. 2.
    G. Y. Zuo, C. J. Wang, J. Han, Y. Q. Li, and G. C. Wang, Phytomedicine, 23, 1814 (2016).CrossRefGoogle Scholar
  3. 3.
    G. Yang and D. Chen, Chem. Biodiv., 5, 1718 (2008).CrossRefGoogle Scholar
  4. 4.
    J. Hu, W. D. Zhang, R. H. Liu, C. Zhang, Y. H. Shen, H. L. Li, M. J. Liang, and X. K. Xu, Chem. Biodiv., 3, 990 (2006).CrossRefGoogle Scholar
  5. 5.
    S. Chakthong, R. Ampaprom, S. Inparn, U. Phetkul, S. Chusri, S. Limsuwan, and S. P. Voravuthikunchai, Nat. Prod. Res., 1 (2018).Google Scholar
  6. 6.
    J. J. Chen, Y. H. Lin, S. H. Day, T. L. Hwang, and I. S. Chen, Food Chem.,125, 282 (2011).CrossRefGoogle Scholar
  7. 7.
    J. Hu, W. D. Zhang, Y. H. Shen, C. Zhang, L. Xu, R. H. Liu, B. Wang, and X. K. Xu, Biochem. Syst. Ecol., 35, 114 (2007).CrossRefGoogle Scholar
  8. 8.
    J. Hu, W. D. Zhang, R. H. Liu, C. Zhang, Y. H. Shen, X. K. Xu, M. J. Liang, and H. L. Li, Chin. J. Chin. Mater. Med., 31, 1689 (2006).Google Scholar
  9. 9.
    G. K. Nikonov and A. I. Saidkhodzhaev, Chem. Nat. Compd., 7, 246 (1971).CrossRefGoogle Scholar
  10. 10.
    K. K. Chebrolu, G. K. Jayaprakasha, J. Jifon, and B. S. Patil, Sep. Purif. Technol., 116, 137 (2013).CrossRefGoogle Scholar
  11. 11.
    Z. Q. Yin, W. C. Ye, and S. X. Zhao, Chin. J. Chin. Mater. Med., 29, 52 (2004).Google Scholar
  12. 12.
    M. Kumagai, A. Watanabe, I. Yoshida, T. Mishima, M. Nakamura, K. Nishikawa, and Y. Morimoto, Biol. Pharm. Bull., 41, 132 (2018).CrossRefGoogle Scholar
  13. 13.
    R. Phatchana and C. Yenjai, Planta Med., 80, 719 (2014).CrossRefGoogle Scholar
  14. 14.
    H. Ishii, T. Ishikawa, H. Wada, H. Miyazaki, Y. Kaneko, and T. Harayama, Chem. Pharm. Bull., 40, 1770 (2008).CrossRefGoogle Scholar
  15. 15.
    T. Kinoshita, J.-B. Wu, and F.-C. Ho, Phytochemistry, 43, 125 (1996).CrossRefGoogle Scholar
  16. 16.
    W. M. Tin, S. Bonomo, and R. W. Scora, Planta Med., 37, 379 (1979).CrossRefGoogle Scholar
  17. 17.
    A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, D. Vistica, C. Hose, J. Langley, P. Cronise, and A. Vaigrowolff, J. Natl. Cancer Inst., 83, 757 (1991).CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunmingP. R. China
  2. 2.University of Chinese Academy of SciencesBeijingP. R. China
  3. 3.College of Biology and ChemistryPuer UniversityPuerP. R. China

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