A new lignanamide derivative, lycichinenamide (1), has been isolated from the root barks of Lycium chinense together with nine known compounds, lyciumamide H (2), 5,2′-dihydroxy-6,7,8,6′-tetramethoxyflavone (3), 7α,8β-3′-O-methylcedrusin (4), smiglabrol (5), trans-N-caffeoyltyramine (6), vanillic acid (7), syringic acid (8), 2,6-dimethoxy-1,4-benzoquinone (9), and 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, lycichinenamide (1), lyciumamide H (2), smiglabrol (5), and trans-N-caffeoyltyramine (6) showed potent inhibition with IC50 values of 18.5 ± 2.1, 21.8 ± 1.8, 12.4 ± 0.3, and 24.6 ± 2.0 μM, respectively, against LPS-induced NO generation. In addition, 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10) exhibited anti-Dengue virus activity with IC50 value of 22.4 ± 1.6 μM against Dengue virus serotype 2 strain PL046.
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This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-010-033-MY3) awarded to Prof. J.-J. Chen. This work was also supported by a grant from the Zuoying Branch of Kaohsiung Armed Forces General Hospital (ZBH 107-27). Hui-Chu Huang, Li-Chai Chen, Tsung-Hsien Chang, and Tong-Fei Zhu have contributed equally to this paper.
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