Isolation, Chemical Modification, and Anticancer Activity of Major Metabolites of the Lichen Parmotrema mesotropum

  • Uppuluri Venkata MallavadhaniEmail author
  • Reddy Srilakshmi Tirupathamma
  • G. Sagarika
  • Sistla Ramakrishna

Extensive chromatographic purification of the chloroform–methanol (1:1) extract of the lichen Parmotrema mesotropum led to the isolation of methyl hematommate (1), methyl-2,4-dihydroxy-3,6-dimethylbenzoate (2), orcinol (3), and atranorin (4). The two major metabolites (1 and 2) were subjected to chemical modification and a total of 15 analogues were synthesized. The synthesized analogues and their parent compounds were evaluated for their anticancer potential against a panel of five human cancer cell lines. Among the tested samples, compound 1g showed potent activity against three cancer cell lines, namely DU145 (IC50 20.07 μM), MCF-7 (IC50 20.94 μM), and U87MG (IC50 25.32 μM). This compound can be considered as lead a molecule for further development.


Lichen Parmotrema mesotropum methyl hematommate methyl 2,4-dihydroxy-3,6-dimethylbenzoate synthetic analogues anticancer activity 



We are thankful to the Director of CSIR-IICT for keen interest and encouragement. We are also thankful to CSIR, New Delhi for the award of a research fellowship to one of us (RST).


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Authors and Affiliations

  • Uppuluri Venkata Mallavadhani
    • 1
    • 2
    Email author
  • Reddy Srilakshmi Tirupathamma
    • 1
    • 2
  • G. Sagarika
    • 3
  • Sistla Ramakrishna
    • 3
  1. 1.Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical TechnologyHyderabadIndia
  2. 2.Academy of Scientific & Innovative ResearchGhaziabedIndia
  3. 3.Applied Biology Division, CSIR-Indian Institute of Chemical TechnologyHyderabadIndia

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