Gliotoxin Analogues from Endophytic Penicillium sp. of Eucommia ulmoides and Their Antimicrobial Activity
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Gliotoxin, displaying this typical bridged disulfide, was described in 1943 . It is one of the better known members of the epipo-lythiodioxopiperazine (ETP) class of fungal metabolites. The structure of the ETP class of fungal products is characterized by the bridged disulfide piperazinedione six-membered ring that appears to be necessary for most of the biological properties of these compounds . Endophytic fungi are eukaryotic organisms that live inside plant tissues and are usually specific at the host species level [3, 4]. Endophytic fungi show high potential as sources of novel antimicrobial, antiviral, anticancer, antioxidant, and insecticidal compounds .
In the course of our search for biologically active metabolites from endophytic fungi from Chinese medicinal plants, a subculture of an isolate of Penicillium sp., obtained from roots of Eucommia ulmoides, was cultivated on potato dextrose agar (PDA). Eucommia ulmoidesOliv. (Eucommiaceae), known as “Du-Zhong,” is...