Neoflavonoid Angelicin Derivatives
- 13 Downloads
Furocoumarins form one of the most important classes of natural flavonoids with photosensitizing action that are used therapeutically for psoriasis, fungal mycosis, and cancer [1, 2]. The simplest angular furocoumarin angelicin (isopsoralen) occurs in plants of the family Apiaceae  and exhibits antioxidant, anti-inflammatory, membrane-stabilizing, and anabolic activity . 4-Alkyl-8-aroyl-9-arylangelicin derivatives exhibited antiviral activity against influenza A (H1N1)  and were patented as agents for cancer treatment . Natural neoflavanoid angelicin derivatives and their analogs with hydrogenated furan rings were isolated from bark of Ochrocarpos punctatus and Mammea neurophylla [7, 8, 9]. Furanoracemosone was isolated from leaves of Mesua racemosa ; its analogs, from bark and fruit of Calophyllum dispar .
Two approaches were previously used to synthesize 4-phenylfuro[2,3-h]coumarins, i.e., annelation of an α-pyrone ring to benzofuran via intramolecular...
- 1.R. Gambari, I. Lampronti, N. Bianchi, C. Zuccato, G. Viola, D. Vedald, and F. Dall’Acqua, Bioact. Heterocycl. III, 265 (2007).Google Scholar
- 4.A. M. Komisarenko, S. M. Komisarenko, and I. F. Sotsiperova, Visn. Farm., No. 3–4, 99 (1995).Google Scholar
- 6.US Pat. 312,317 (2009).Google Scholar
- 13.S. M. Desai and K. N. Trivedi, Indian J. Chem., Sect B: Org. Chem. Incl. Med. Chem., 24, 47 (1985).Google Scholar
- 14.D. B. Limaye, R. H. Munje, G. S. Shenolikar, and S. S. Talwalkar, Rasayanam 1, 187 (1939); Chem. Abstr., 34, 5071 (1940).Google Scholar