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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 696–699 | Cite as

New Benzylated Alkamide from the Roots of Lepidium meyenii

  • W. X. Liu
  • M. Dong
  • R. Q. Zhang
  • Z. H. Ma
  • Q. F. Yang
  • Y. J. Chen
  • Y. Q. Ye
  • L. M. Liao
  • P. Cheng
  • Z. Y. JiangEmail author
  • M. Zhou
Article
  • 3 Downloads

A new benzylated alkamide, N-(3-methoxybenzyl)hexadec-9Z-enamide (1), and a known analogue (2) were isolated from the roots of Lepidium meyenii. Their structures were elucidated by extensive NMR and MS spectroscopic analyses. All the isolated alkamides were evaluated for their cytotoxicity against five human cancer cell lines but found to be insignificant at concentrations up to 40 μM.

Keywords

Lepidium meyenii benzylated alkamides cytotoxicity 

Notes

Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21262048 and 31560099) and the Programs for Open Project from Key Laboratory of Tobacco Technology and Equipment Research (No. 2016GYSYS03).

References

  1. 1.
    Y. Wang, Y. Wang, B. McNeil, and L. M. Harvey, Food Res. Int., 40, 783 (2007).CrossRefGoogle Scholar
  2. 2.
    J. Rubio, S. Yucra, M. Gasco, and G. F. Gonzales, Toxicol. Mech. Methods, 21, 628 (2011).CrossRefGoogle Scholar
  3. 3.
    F. Uchiyama, T. Jikyo, R. Takeda, and M. Ogata, J. Ethnopharmacol., 151, 897 (2014).CrossRefGoogle Scholar
  4. 4.
    B. L. Zheng, K. He, C. H. Khim, L. Rogers, Y. Shao, Z. Y. Huang, Y. Lu, S. J. Yan, L. C. Qien, and Q. Y. Zheng, Urology, 55, 598 (2000).CrossRefGoogle Scholar
  5. 5.
    R. Vecera, J. Orolin, N. Skottova, L. Kazdova, O. Oliyarnik, J. Ulrichova, and V. Simanek, Plant Food. Hum. Nutr., 62, 59 (2007).CrossRefGoogle Scholar
  6. 6.
    W. Wang, Y. Zou, Q. Li, R. W. Mao, X. J. Shao, D. Jin, D. H. Zheng, T. Zhao, H. F. Zhu, L. Zhang, L. Q. Yang, and X. Y. Wu, Process Biochem., 51, 542 (2016).CrossRefGoogle Scholar
  7. 7.
    M. Zhou, H. Y. Ma, Z. H. Liu, G. Y. Yang, G. Du, Y. Q. Ye, G. P. Li, and Q. F. Hu, J. Agr. Food Chem., 65, 1887 (2017).CrossRefGoogle Scholar
  8. 8.
    M. Zhou, H. Y. Ma, H. H. Xing, P. Li, G. P. Li, H. C. Geng, Q. F. Hu, and G. Y. Yang, Org. Lett., 19, 4952 (2017).CrossRefGoogle Scholar
  9. 9.
    M. Y. Yu, X. J. Qin, L. D. Shao, X. R. Peng, L. Li, H. Yang, and M. H. Qiu, Tetrahedron Lett., 58, 1684 (2017).CrossRefGoogle Scholar
  10. 10.
    M. Zhou, R. Q. Zhang, Y. J. Chen, L. M. Liao, Y. Q. Sun, Z. H. Ma, Q. F. Yang, P. Li, Y. Q. Ye, and Q. F. Hu, Phytochem. Lett., 23, 137 (2018).CrossRefGoogle Scholar
  11. 11.
    H. Wu, C. J. Kelley, A. Pino-Figueroa, H. D. Vu, and T. J. Maher, Bioorgan. Med. Chem., 21, 5188 (2013).CrossRefGoogle Scholar
  12. 12.
    J. P. Zhao, I. Muhammad, D. C. Dunbar, J. Mustafa, and I. A. Khan, J. Agric. Food Chem., 53, 690 (2005).CrossRefGoogle Scholar
  13. 13.
    M. Aursand and H. Grasdalen, Chem. Phys. Lipids, 62, 239 (1992).CrossRefGoogle Scholar
  14. 14.
    M. Zhou, K. Zhou, X. M. Gao, Z. Y. Jiang, J. J. Lv, Z. H. Liu, G. Y. Yang, M. M. Miao, C. T. Che, and Q. F. Hu, Org. Lett., 17, 2638 (2015).CrossRefGoogle Scholar
  15. 15.
    L. J. Reed and H. Muench, Am. J. Epidemiol., 27, 493 (1938).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • W. X. Liu
    • 1
  • M. Dong
    • 1
  • R. Q. Zhang
    • 1
  • Z. H. Ma
    • 1
  • Q. F. Yang
    • 1
  • Y. J. Chen
    • 1
  • Y. Q. Ye
    • 1
  • L. M. Liao
    • 1
  • P. Cheng
    • 1
  • Z. Y. Jiang
    • 1
    Email author
  • M. Zhou
    • 1
  1. 1.School of Chemistry and EnvironmentYunnan Minzu UniversityKunmingP. R. China

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