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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 685–688 | Cite as

A New Totarane Diterpenoid from the Rhizomes of Isodon lophanthoides

  • Wei Xu
  • Chao-Jiang Xiao
  • Jun-Zhe Sun
  • Pan-Pan Zhang
  • Jing-Wen Wang
  • Xiang Dong
  • Bei JiangEmail author
Article
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A new totarane diterpenoid, 7β,15-dihydroxytotarol-19-oic acid (1), along with six known diterpenoids (2–7) and seven known triterpenoids (8–14), were isolated from the EtOAc-soluble fraction of the 70% acetone extract of rhizomes of Isodon lophanthoides. Their structures were elucidated based on the analysis of extensive spectroscopic data. The antimalarial activities of all the isolated diterpenoids were measured by the β-hematin formation inhibition assay in vitro. Compounds 2 and 4 showed moderate activities.

Keywords

Isodon lophanthoides Labiatae chemical constituents totarane diterpenoids β-hematin formation inhibition activity 

Notes

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 81460532 and 81641187).

References

  1. 1.
    Editorial Committee of the Flora of China of Chinese Academy of Science, Flora of China, Vol. 66, Science Press, Beijing, 1997, 479 pp.Google Scholar
  2. 2.
    Editorial Board of China Herbal, and State Administration of Traditional Chinese Medicine, China Herbal, Vol. 19, Scientific and Technical Publishers, Shanghai, 1999, 154 pp.Google Scholar
  3. 3.
    H. D. Sun, S. X. Huang, and Q. B. Han, Nat. Prod. Rep., 23, 673 (2006).CrossRefGoogle Scholar
  4. 4.
    M. Liu, W.-G. Wang, H.-D. Sun, and J.-X. Pu, Nat. Prod. Rep., 34, 1090 (2017).CrossRefGoogle Scholar
  5. 5.
    L. Lin, Y. Dong, B. Yang, and M. Zhao, Comb. Chem. High Throughput Screen., 14, 720 (2011).CrossRefGoogle Scholar
  6. 6.
    K. Sato, K. Sugawara, H. Takeuchi, H.-S. Park, T. Akiyama, T. Koyama, Y. Aoyagi, K. Takeya, T. Tsugane, and S. Shimura, Chem. Pharm. Bull., 56, 1691 (2008).CrossRefGoogle Scholar
  7. 7.
    B.-P. Ying and I. Kubo, Phytochemistry, 30, 1951 (1991).CrossRefGoogle Scholar
  8. 8.
    W. Zhou, H. Xie, P. Wu, and X. Wei, Food Chem., 136, 1110 (2013).CrossRefGoogle Scholar
  9. 9.
    B. Huang, Z.-Y. Huang, C.-J. Xiao, X. Dong, and B. Jiang, Helv. Chim. Acta, 98, 527 (2015).CrossRefGoogle Scholar
  10. 10.
    S. B. Mahato and A. P. Kundu, Phytochemistry, 37, 1517 (1994).CrossRefGoogle Scholar
  11. 11.
    L.-B. Wu, C.-J. Xiao, X. Jiang, L. Qiu, X. Dong, and B. Jiang, Chem. Biodiv., 12, 1229 (2015).CrossRefGoogle Scholar
  12. 12.
    S. C. Gnoatto, A. Dassonville-Klimpt, S. Da Nascimento, P. Galera, K. Boumediene, G. Gosmann, P. Sonnet, and S. Moslemi, Eur. J. Med. Chem., 43, 1865 (2008).CrossRefGoogle Scholar
  13. 13.
    J. L. Jin, Y. L. Yong, J. E. Heo, S. Lee, J. M. Kim, and H. S. Yun-Choi, Arch. Pharm. Res., 27, 376 (2004).CrossRefGoogle Scholar
  14. 14.
    D. Borchman, M. C. Yappert, S. E. Milliner, R. J. Smith, and R. Bhola, Lipids, 48, 1269 (2013).CrossRefGoogle Scholar
  15. 15.
    I. Slavyana, T. Vesselin, Y. Norihiko, M. C. Yappert, B. Douglas, and G. Georgi As, Int. J. Mol. Sci., 16, 21813 (2015).CrossRefGoogle Scholar
  16. 16.
    K. K. Ncokazi and T. J. Egan, Anal. Biochem., 338, 306 (2005).CrossRefGoogle Scholar
  17. 17.
    K. J. Wicht, J. M. Combrinck, P. J. Smith, R. Hunter, and T. J. Egan, J. Med. Chem., 59, 6512 (2016).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Wei Xu
    • 1
  • Chao-Jiang Xiao
    • 1
    • 2
  • Jun-Zhe Sun
    • 1
  • Pan-Pan Zhang
    • 1
  • Jing-Wen Wang
    • 1
  • Xiang Dong
    • 1
    • 2
  • Bei Jiang
    • 1
    • 2
    Email author
  1. 1.College of Pharmacy and ChemistryDali UniversityDaliP. R. China
  2. 2.Institute of Materia MedicaDali UniversityDaliP. R. China

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