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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 658–664 | Cite as

Synthesis and Antioxidant Properties of Hydroxycinnamic Acid Derivatives Containing Isobornyl Substituents

  • I. A. DvornikovaEmail author
  • E. V. Buravlev
  • I. V. Fedorova
  • O. G. Shevchenko
  • I. Yu. Chukicheva
  • A. V. Kuchin
Article

New hydroxycinnamic acid derivatives were synthesized by reacting malonic acid and 4-hydroxybenzaldehydes with isobornyl and/or alkyl substituents. The antiradical, antioxidant, and membrane-protective activities were assessed in various in vitro models. The bulk of the substituent(s) in the o-position(s) relative to the phenol hydroxyl had a substantial effect on the antioxidant properties of the tested acids.

Keywords

monoterpenoids (E)-3-(4-hydroxyphenyl)acrylic acid antioxidant activity membrane-protective activity oxidative hemolysis 

Notes

Acknowledgment

The research was financially supported by the RFBR in the framework of science Project No. 18-03-00950_a.

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. A. Dvornikova
    • 1
    Email author
  • E. V. Buravlev
    • 1
  • I. V. Fedorova
    • 1
  • O. G. Shevchenko
    • 2
  • I. Yu. Chukicheva
    • 1
  • A. V. Kuchin
    • 1
  1. 1.Institute of Chemistry, Komi Scientific CenterUral Branch, Russian Academy of SciencesSyktyvkarRussian Federation
  2. 2.Institute of Biology, Komi Scientific CenterUral Branch, Russian Academy of SciencesSyktyvkarRussian Federation

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