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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 618–621 | Cite as

Two New Naphthalene Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis sp.

  • Xue-Mei Li
  • Yi-Cheng Zeng
  • Jian-Hua Chen
  • Ye-Kun Yang
  • Jing Li
  • Lin Ye
  • Gang Du
  • Min Zhou
  • Qiu-Fen Hu
  • Guangyu-Yang
  • Hai-Ying YangEmail author
  • Yan-Qing Duan
Article
  • 16 Downloads

Two new naphthalene derivatives, 5-methoxy-2-methyl-7-(3-methyl-2-oxobut-3-enyl)-1-naphthaldehyde (1) and 2-(hydroxymethyl)-5-methoxy-7-(3-methyl-2-oxobut-3-enyl)-1-naphthaldehyde (2), together with two known naphthalene derivatives (3 and 4), were isolated from the fermentation products of an endophytic fungus Phomopsis sp. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1 and 2 showed good inhibition with IZD of 14.5 ± 1.2 and 15.2 ± 1.3 mm, respectively.

Keywords

naphthalene derivatives endophytic fungus Phomopsis sp. anti-MRSA activity 

Notes

Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081, and 31400303), the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (Nos. 2015539200340277 and 2016JC03).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Xue-Mei Li
    • 1
  • Yi-Cheng Zeng
    • 1
  • Jian-Hua Chen
    • 1
  • Ye-Kun Yang
    • 1
  • Jing Li
    • 1
  • Lin Ye
    • 1
  • Gang Du
    • 2
  • Min Zhou
    • 2
  • Qiu-Fen Hu
    • 2
  • Guangyu-Yang
    • 1
  • Hai-Ying Yang
    • 2
    Email author
  • Yan-Qing Duan
    • 1
  1. 1.China Tobacco Yunnan Industrial Co., LtdKunmingP. R. China
  2. 2.Key Laboratory of Chemistry in Ethnic Medicinal ResourcesYunnan Minzu UniversityKunmingP. R. China

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