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Neuroprotective Aurones from Sophora japonica

  • Qinge MaEmail author
  • Rongrui WeiEmail author
  • Zhipei Sang
Article
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A new aurone, named (Z)-4,5-methylenedioxy-6-hydroxybenzene-2[(2′,3′,4′-trimethoxy)-2-methyl-2(4-methyl-3-penten-1-yl)-2H-1-benzopyran-5-yl)methylene]-3-benzofuranon (1), and nine known aurones (2–10) were isolated from Sophora japonica L. for the first time. Compounds 1–10 were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. Compounds 1, 3, 8, and 10 exhibited significant neuroprotective activities with IC50 values in the range of 2.89–6.02 μM.

Keywords

Sophora japonica L. aurone neuroprotective 

Notes

Acknowledgment

This work was supported by the Key Scientific Research Project of Colleges and Universities in Henan Province (No. 19A350006), the National Natural Science Foundation of China (No. 81803843), and the Standard Revision Research Project of National Pharmacopoeia Committee (No. 2018Z090). We are grateful to the Department of Instrumental Analysis of Nayang Normal University and Jiangxi University of Traditional Chinese Medicine for measurements of UV, IR, NMR, and MS.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic MedicineJiangxi University of Traditional Chinese MedicineNanchangP. R. China
  2. 2.College of Chemistry and Pharmaceutical EngineeringNanyang Normal UniversityNanyangP. R. China

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